Prognostic and diagnostic significance of circRNAs expression in hepatocellular carcinoma patients: A meta-analysis
Prognostic and diagnostic significance of circRNAs expression in hepatocellular carcinoma patients: A meta-analysis
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DOI：
10.1002/cam4.1939
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发表时间：
2019-03-01
期刊：
影响因子：
4
通讯作者：
Shao, Zengwu
中科院分区：
文献类型：
--
作者：
Huang, Xin;Zhang, Weiyue;Shao, Zengwu
环状rna （circRNAs）作为一种新型生物标志物在各种癌症中得到了广泛的研究。我们研究的目的是揭示人类肝细胞癌（HCC）中环状rna的临床病理、预后和诊断特征。系统检索PubMed、Scopus、Web of Science （WOS）、EMBASE和Cochrane Library数据库。纳入了报道环状rna与HCC患者临床病理、预后和诊断价值之间关系的符合条件的研究。合并优势比（ORs）和95%置信区间（CIs）用于评估临床病理参数、敏感性和特异性，风险比（hr）用于评估总生存期（OS）。我们的研究纳入了17项符合条件的研究，其中7项用于临床病理特征，10项用于预后，8项用于诊断。在临床病理参数方面，高表达的致癌circRNAs与较差的临床病理特征显著相关，而抑癌circRNAs则相反。在预后价值方面，致癌circRNAs对总生存率有负面影响（OS: HR = 3.39, 95%Cl: 2.59-4.19），而肿瘤抑制circRNAs的高表达与改善生存结果相关（OS: HR = 0.46, 95%Cl: 0.37-0.56）。综合诊断结果显示，曲线下面积（AUC）为0.84，区分HCC与对照组的敏感性为82%，特异性为72%。我们的研究表明，环状rna可能是HCC预后和诊断价值的重要生物标志物。
Circular RNAs (circRNAs) as novel biomarkers are widely investigated in various cancers. The aim of our study was to reveal the clinicopathological, prognostic, and diagnostic features of circRNAs in human hepatocellular carcinoma (HCC). A systematical search was conducted on PubMed, Scopus, Web of Science (WOS), EMBASE, and the Cochrane Library databases. Eligible studies reporting on the association among circRNAs and clinicopathological, prognostic, diagnostic values of HCC patients were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were utilized to assess clinicopathological parameters, sensitivity, and specificity, and hazard ratios (HRs) were to evaluate overall survival (OS). 17 eligible studies which included 7 for clinicopathological features, 10 for prognosis, and 8 for diagnosis were in our study. As for clinicopathological parameters, high expression of oncogenic circRNAs had a significant association with poor clinicopathological features and tumor-suppressor circRNAs proved the contrary. In terms of the prognostic values, oncogenic circRNAs had a negative influence on overall survival (OS: HR = 3.39, 95%Cl: 2.59-4.19), and high expression of tumor-suppressor circRNAs was relevant to improved survival outcomes (OS: HR = 0.46, 95%Cl: 0.37-0.56). The pooled diagnostic outcomes indicated an area under the curve (AUC) of 0.84, with sensitivity of 82% and specificity of 72% in discriminating HCC from controls. Our study indicates that circRNAs may be important biomarkers for prognostic and diagnostic values of HCC.