Rural residence and adoption of a novel HIV therapy in a national, equal-access healthcare system.

Rural residence and adoption of a novel HIV therapy in a national, equal-access healthcare system.
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DOI:
10.1007/s10461-011-0107-8
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发表时间:
2013-01
期刊:
影响因子:
4.4
通讯作者:
Vaughan-Sarrazin, Mary
Vaughan-Sarrazin, Mary
中科院分区:
医学2区
文献类型:
--
作者:
Ohl, Michael;Lund, Brian;Belperio, Pamela S.;Goetz, Matthew Bidwell;Rimland, David;Richardson, Kelly;Justice, Amy;Perencevich, Eli;Vaughan-Sarrazin, Mary

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农村艾滋病毒感染者在获得护理方面面临障碍,这可能会影响采用先进的治疗方法。我们进行了一项回顾性队列研究,以确定在国家退伍军人事务(VA)医疗保健中采用雷特格韦(第一种HIV整合酶载体)的城乡差异。在2007年10月FDA批准雷特格韦治疗时,有1,222名退伍军人有临床适应症,其中223人(19.1%)居住在农村地区。城市人群在180天(17.3% vs. 11.2%,P = 0.02)和360天(27.5% vs. 19.7%,P = 0.02)内启动雷特格韦的可能性高于农村人群,但在720天时,这一差距略有缩小(36.3% vs. 31.8%,P = 0.19)。在调整患者特征的多变量分析中,城市居住预测了180天(比值比1.72,95% CI 1.09-2.70)和360天(OR 1.63,95% CI 1.13-2.34)内采用雷特格韦,但不是720天(OR 1.26,95% CI 0.84-1.87)。需要努力减少采用艾滋病毒治疗进展方面的地理差异。
Rural persons with HIV face barriers to care that may influence adoption of advances in therapy. We performed a retrospective cohort study to determine rural–urban variation in adoption of raltegravir—the first HIV integrase inhibitor—in national Veterans Afffairs (VA) healthcare. There were 1,222 veterans with clinical indication for raltegravir therapy at time of its FDA approval in October 2007, of whom 223 (19.1%) resided in rural areas. Urban persons were more likely than rural to initiate raltegravir within 180 days (17.3% vs. 11.2%, P = 0.02) and 360 days (27.5% vs. 19.7%, P = 0.02), but this gap narrowed slightly at 720 days (36.3% vs. 31.8%, P = 0.19). In multivariable analysis adjusting for patient characteristics, urban residence predicted raltegravir adoption within 180 days (odds ratio 1.72, 95% CI 1.09–2.70) and 360 days (OR 1.63, 95% CI 1.13–2.34), but not 720 days (OR 1.26, 95% CI 0.84–1.87). Efforts are needed to reduce geographic variation in adoption of advances in HIV therapy.
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