Dietary intake polycyclic aromatic hydrocarbons (PAHs) and associated cancer risk in a cohort of Chinese urban adults: Inter- and intra-individual variability.
Dietary intake polycyclic aromatic hydrocarbons (PAHs) and associated cancer risk in a cohort of Chinese urban adults: Inter- and intra-individual variability.
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DOI：
10.1016/j.chemosphere.2015.11.019
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发表时间：
2016-02
期刊：
影响因子：
8.8
通讯作者：
Zhang JJ
中科院分区：
文献类型：
--
作者：
Duan X;Shen G;Yang H;Tian J;Wei F;Gong J;Zhang JJ
膳食摄入是多环芳烃（PAHs）的主要暴露途径之一，尤其是在中国人群中，因为食物通常是通过烧烤和/或油炸制备的，这会产生高水平的PAHs。本文采用“双碟法”对100名中国城市居民的多环芳烃每日膳食摄入量进行了测定。苯并（a）芘的DDI范围为0.06 μg/天至13.5 μg/天，中位数为0.69 μg/天，受试者之间差异很大。PAH饮食摄入导致的中位终身癌症风险增量（ILCR）为6.65×10−5（四分位数范围为4.41×10−5至1.02×10−4）。几种高PAH含量的食物，如烧烤，烟熏或油炸肉类，占总DDI的13%左右。生食的使用可能大大低估了多环芳烃的膳食摄入量和相关的暴露风险。从不同季节的食物采样结果表明，在一个人的季节性变化可能会显着地在人口和更多的未来研究与长期调查的食物摄入和污染物暴露的总体变化。研究结果表明，测量实际摄入的食物更适合于膳食摄入暴露评估，在研究设计和数据分析中应考虑个体内差异。
Dietary intake is one of the major exposure pathways of polycyclic aromatic hydrocarbons (PAHs), especially in Chinese people because foods are often prepared with grilling and/or frying that would produce high levels of PAHs. In this paper, we assessed daily dietary intakes (DDI) of PAHs, using a “duplicate plate method”, among 100 Chinese urban residents. The DDI of bento(a)pyrene ranged from 0.06 μg per day to 13.5 μg per day with a median of 0.69 μg per day, varying largely across subjects. The median Incremental Lifetime Cancer Risk (ILCR) attributable to PAH dietary intake was 6.65×10−5 (4.41×10−5 to 1.02×10−4 as inter-quartile range). The contribution of several high-PAH containing foods like barbecued, smoked or deep-fried meats to the overall DDIs was about 13%. The use of raw foods may underestimate dietary intake of PAHs and associated exposure risk considerably. Results from foods sampled in different seasons suggested that seasonal variability within an individual may contribute notably to overall variability measured in a population and more future studies with longer-term investigation on food ingestion and pollutant exposure are needed. The study indicate that measuring actually consumed foods is more appropriate for dietary intake exposure assessment, and intra-individual variance should be taken into account during study design and data analysis.