Phasic lung inflation shortens inspiration and respiratory period in the lung-attached neonate rat brain stem spinal cord.
Phasic lung inflation shortens inspiration and respiratory period in the lung-attached neonate rat brain stem spinal cord.
复制标题
阶段性肺充气缩短了附肺新生大鼠脑干脊髓的吸气和呼吸周期。
DOI：
10.1152/jn.2000.83.5.3165
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发表时间：
2000
影响因子：
2.5
通讯作者：
Feldman,JL
中科院分区：
文献类型：
--
作者：
Mellen,NM;Feldman,JL
在完整的哺乳动物中，吸气时的肺部充气终止了吸气(Breuer-Hering吸气反射，BHI)，肺传入神经的存在增加了呼吸频率。为了测试这些反应是否可以在体外获得，使用了保留肺和迷走神经的新生大鼠脑干/脊髓标本。结果发现：1)BHI可在体外复制；2)吸气时肺相性充气引起呼吸频率增加，随充气延迟期延长，呼吸效率下降；3)呼吸频率增加不需要吸气缩短。
In intact mammals, lung inflation during inspiration terminates inspiration (Breuer-Hering inspiratory reflex, BHI) and the presence of lung afferents increases respiratory frequency. To test whether these responses could be obtained in vitro, a neonate rat brain stem/spinal cord preparation retaining the lungs and their vagal innervation was used. It was found that1) the BHI could be replicated in vitro,2) phasic lung inflation during inspiration caused increased respiratory frequency with declining efficacy as inflation delay increased, and3) increased respiratory frequency did not require inspiratory shortening.