Isoflavonoids from Ficus benjamina and their inhibitory activity on BACE1.
Isoflavonoids from Ficus benjamina and their inhibitory activity on BACE1.
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DOI：
10.1055/s-0032-1315001
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发表时间：
2012-08
期刊：
影响因子：
2.7
通讯作者：
Williams PG
中科院分区：
文献类型：
--
作者：
Dai J;Shen D;Yoshida WY;Parrish SM;Williams PG
Examination of an active extract of the fruit of Ficus benjamina var. nuda (Miq.) Barrett (Moraceae) has led to the isolation of six new isoflavones and two coumarano-chroman-4-one, along with fifteen known compounds. The structures of the eight new compounds were elucidated on the basis of extensive NMR experiments and mass spectrometric measurements. The inhibitory activity of the compounds on the proteolytic cleavage of amyloid precursor protein by the aspartic protease BACE1 was evaluated. Both coumarano-chroma-4-ones and some isoflavones showed moderate activity in this assay.
