Efficacy and safety of extended-release, once-daily tramadol in chronic pain: A randomized 12-week clinical trial in osteoarthritis of the knee
Efficacy and safety of extended-release, once-daily tramadol in chronic pain: A randomized 12-week clinical trial in osteoarthritis of the knee
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DOI：
10.1016/j.jpainsymman.2003.11.006
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发表时间：
2004-07-01
影响因子：
4.7
通讯作者：
Albert, K
中科院分区：
文献类型：
--
作者：
Babul, N;Noveck, R;Albert, K
评价了盐酸曲马多缓释制剂（曲马多ER）每日一次治疗中重度骨关节炎（OA）慢性疼痛的疗效和安全性。这是一项随机、双盲、安慰剂对照、平行组、为期12周的研究。符合美国风湿病学会诊断标准（定义为膝关节疼痛和存在骨赘，加上年龄>50岁，晨僵）的经X线片证实的膝关节OA合格患者
The efficacy and safely of a once-daily extended-release formulation of tramadol hydrochloride (tramadol ER) was evaluated in Patients with moderate to severe chronic pain of osteoarthritis (OA). This was a randomized, double-blind, placebo-controlled, parallel-group, 12-week study. Eligible patients with radiographically confirmed OA of the knee meeting the American College of Rheumatology diagnostic criteria, defined by knee, pain and presence of osteophytes, plus at least age >50 years, morning stiffness