Interaction between superficial layers of the entorhinal cortex and the hippocampus in normal and epileptic temporal lobe
Interaction between superficial layers of the entorhinal cortex and the hippocampus in normal and epileptic temporal lobe
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DOI：
10.1016/s0920-1211(98)00050-3
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发表时间：
1998-09-01
影响因子：
2.2
通讯作者：
Heinemann, U
中科院分区：
文献类型：
--
作者：
Gloveli, T;Schmitz, D;Heinemann, U
内嗅皮质（EC）是感觉信息进入海马结构的主要门户。从内侧EC的第II层和第III层到海马的信息流以频率依赖的方式被调节。传播低镁2+诱导癫痫样活动EC海马不同的切片从正常和点燃大鼠，在成年与幼年大鼠。在正常大鼠的脑片中，EC中的低Mg 2+诱导的癫痫样活动对CA3和CA1区域仅具有中度影响，显然是由齿状回中的强大抑制门控的。在点燃大鼠和幼年大鼠的脑片中，通过EC海马脑片促进了癫痫样事件和晚期复发性放电的传播。颞叶癫痫与内侧EC第III层的选择性病变相关。癫痫期间内侧EC的第III层细胞的这种损失可能导致从EC到海马的频率依赖性信息流的干扰，并且因此导致与这些疾病相关的认知障碍。(C)1998 Elsevier Science B.V.保留所有权利。
The entorhinal cortex (EC) is a major gateway for sensory information into the hippocampal formation. The information flow from layer II and III of the medial EC to the hippocampus is regulated in a frequency dependent manner. Spread of low Mg2+-induced epileptiform activity from EC to hippocampus differs in slices obtained from normal and kindled rats, and in adult versus juvenile rats. In slices from normal rats, low Mg2+-induced epileptiform activity in the EC had only moderate effects on the areas CA3 and CA1, apparently gated by powerful inhibition in the dentate gyrus. In slices from kindled rats, and from juvenile rats, there is facilitated propagation of the seizure-like events and late recurrent discharges through the EC-hippocampal slice. Temporal lobe epilepsy is associated with selective lesions in layer III of the medial EC. Such loss of layer III cells of the medial EC during epilepsy may contribute to the disturbance of frequency dependent information flow from the EC to the hippocampus, and, therefore, to the cognitive impairments associated with these disorders. (C) 1998 Elsevier Science B.V. All rights reserved.