Postsynaptic receptor trafficking underlying a form of associative learning
Postsynaptic receptor trafficking underlying a form of associative learning
复制标题
DOI：
10.1126/science.1103944
复制
发表时间：
2005-04-01
期刊：
影响因子：
56.9
通讯作者：
Malinow, R
中科院分区：
文献类型：
--
作者：
Rumpel, S;LeDoux, J;Malinow, R
为了阐明学习过程中大脑中发生的分子、细胞和电路变化，我们研究了谷氨酸受体亚型在恐惧条件反射中的作用。在这种形式的学习中，动物将两种刺激联系起来，例如音调和电击。在这里，我们报告说，恐惧条件反射驱动AMPA型谷氨酸受体进入外侧杏仁核中大部分突触后神经元的突触，这是一个对学习过程至关重要的大脑结构。此外，记忆力下降，如果AMPA受体突触掺入被阻断在10至20%的外侧杏仁核神经元。因此，外侧杏仁核中的记忆编码是由AMPA受体运输介导的，分布广泛，几乎没有冗余。
To elucidate molecular, cellular, and circuit changes that occur in the brain during learning, we investigated the rote of a glutamate receptor subtype in fear conditioning. In this form of learning, animals associate two stimuli, such as a tone and a shock. Here we report that fear conditioning drives AMPA-type glutamate receptors into the synapse of a large fraction of postsynaptic neurons in the lateral amygdala, a brain structure essential for this learning process. Furthermore, memory was reduced if AMPA receptor synaptic incorporation was blocked in as few as 10 to 20% of lateral amygdala neurons. Thus, the encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking, is widely distributed, and displays little redundancy.