Hypoxia and the radiation response of tumors.
Hypoxia and the radiation response of tumors.
复制标题
缺氧与肿瘤的放射反应。
DOI：
10.1007/978-1-4684-7790-0_3
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发表时间：
1983
影响因子：
--
通讯作者：
M. Pallavicini
中科院分区：
文献类型：
--
作者：
R. Hill;M. Pallavicini
缺氧对肿瘤体内辐射反应的影响被证明是用于测量治疗后的细胞存活和生长延迟。使用这些终点对KHT肉瘤的结果，然后展示了各种参数的影响，这些参数有望控制肿瘤氧合：血流量，血pO2，血氧携带能力和组织耗氧量。固有血流量与肿瘤缺氧水平无关，但血流量的急性减少确实会导致肿瘤氧合减少。改变血PaO2或携氧能力会改变缺氧水平，这与预测一致，但目前只对某些方面进行了研究。控制正常组织氧合和补偿任何缺陷的复杂反馈机制不能被认为在肿瘤中有效地起作用。
The effect of hypoxia on the in vivo radiation response of tumors is demonstrated both for the measurement of cell survival and growth delay following treatment. Results using these endpoints for the KHT Sarcoma are then presented to demonstrate the effect of various parameters which are expected to control tumor oxygenation: blood flow, blood pO2, blood oxygen carrying capacity and tissue consumption of oxygen. Intrinsic blood flow does not correlate with the level of hypoxia in the tumor, but acute reductions in blood flow do result in decreases in tumor oxygenation. Changing the blood PaO2 or the oxygen carrying capacity change the level of hypoxia as predicted, but only certain aspects have been studied. The intricate feedback mechanism which controls normal tissue oxygenation and compensates for any deficiencies cannot be assumed to work effectively in tumors.