Interaction between rifaximin and dietary fibre in patients with diverticular disease
Interaction between rifaximin and dietary fibre in patients with diverticular disease
复制标题
DOI：
10.1111/j.1365-2036.2007.03266.x
复制
发表时间：
2007-04-01
影响因子：
7.6
通讯作者：
Sturniolo, G. C.
中科院分区：
文献类型：
--
作者：
D'Inca, R.;Pomerri, F.;Sturniolo, G. C.
背景资料：利福昔明联合膳食纤维的周期性给药通过一种尚不明确的机制实现了单纯性憩室病（DD）的症状缓解。目的：研究利福昔明和膳食纤维的组合对肠道菌群产氢和口-肛门通过时间的影响。方法：在一项对照、双盲交叉试验中，64名无并发症的DD患者被给予麸皮（20 g/天），并随机接受利福昔明（1200 mg/天）或安慰剂治疗14天。结果：利福昔明治疗后总体症状评分显著降低（7.1 +/- 4.1 ~ 4.1 +/- 3.3; P < 0.005），但安慰剂治疗后没有显著降低（6.8 +/- 3.8 ~ 6.1 +/- 3.5）。安慰剂组的产氢量从198 +/- 134增加到267 +/- 161 ppm/min，而利福昔明组的产氢量从222 +/- 187减少到166 +/- 131 ppm/min（P = 0.05）。安慰剂组总口肛门通过时间从56.1 +/- 28.2小时缩短至51.3 +/- 28.0小时，利福昔明治疗患者从54.4 +/- 31.9小时缩短至45.1 +/- 32.4小时（P < 0.05）。结论：利福昔明给药通过防止细菌降解，改善膳食纤维对无并发症DD的益处。
Background: Cyclic administration of rifaximin in association with dietary fibre achieves symptomatic relief in uncomplicated diverticular disease (DD) by means of a still undefined mechanism.Aim: To investigate the effects of a combination of rifaximin and fibre on both hydrogen production by intestinal microflora and oro-anal transit time.Methods: In a controlled, double-blind crossover trial, 64 patients with uncomplicated DD were given bran (20 g/day) and randomly treated with rifaximin (1200 mg/day) or a placebo for 14 days. Evaluation was based on clinical status, breath test, oro-anal transit time and faecal weight.Results: The global symptomatic score was significantly reduced after rifaximin (7.1 +/- 4.1 to 4.1 +/- 3.3; P < 0.005) but not after placebo (6.8 +/- 3.8 to 6.1 +/- 3.5). Hydrogen production significantly increased after placebo from 198 +/- 134 to 267 +/- 161 ppm/min, while Rifaximin reduced it from 222 +/- 187 to 166 +/- 131 ppm/min (P = 0.05). The total oro-anal transit time decreased from 56.1 +/- 28.2 to 51.3 +/- 28.0 h in placebo and from 54.4 +/- 31.9 to 45.1 +/- 32.4 h (P < 0.05) in rifaximin-treated patients.Conclusions: The administration of rifamixin improves the benefits of dietary fibre in uncomplicated DD by preventing its bacterial degradation.