Failure of attention focus and cognitive control in schizophrenia patients with auditory verbal hallucinations: Evidence from dichotic listening
Failure of attention focus and cognitive control in schizophrenia patients with auditory verbal hallucinations: Evidence from dichotic listening
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DOI：
10.1016/j.schres.2013.04.005
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发表时间：
2013-07-01
影响因子：
4.5
通讯作者：
Loberg, Else-Marie
中科院分区：
文献类型：
--
作者：
Hugdahl, Kenneth;Nygard, Merethe;Loberg, Else-Marie
听觉言语幻觉（AVHs）是缺乏外部来源的言语感知，在现象学上被体验为“听到声音”。然而，精神分裂症患者AVH体验的感知来源并不能解释为什么“声音”会耗尽患者的注意力和认知能力，使他们无法将注意力从“声音”上转移开来，并在认知上抑制这种体验。我们最近报道了avh是如何干扰语音感知的，使用了一个二分聆听实验范式。我们现在扩展了这一发现，报告了AVHs对注意力和认知控制造成的干扰，使用了相同的二元聆听范式的轻微变化。148例患者被要求注意并从右耳或左耳的双音节中任选一个进行报告。然后，我们将他们幻觉项目的PANSS得分与二分听力任务的表现得分相关联。结果表明，当被指示注意右耳时，中耳部干扰了报告右耳音节的能力，这是无法注意外部言语刺激的标志。当被指示将注意力集中在左侧时，avh干扰了报告左耳音节的能力，这是无法使用认知控制来抑制对“声音”的关注的标志。情绪戒断（N2）负性症状的相关均不显著。相关性在方差分析中得到证实，在高和低症状评分组之间存在相应的显著组差异。因此，该结果扩展了我们之前关于AVHs的感知起源的发现，表明AVHs干扰了患者关注周围外部世界的能力，以及一旦出现“声音”时抑制或抑制“声音”的能力。未来的研究应明确AVHs发生的神经元基础以及注意和认知控制方面的基础。(C) 2013 Elsevier b.v.版权所有
Auditory verbal hallucinations (AVHs) are speech perceptions that lack an external source, phenomenologically experienced as "hearing voices". A perceptual origin of an AVH experience in patients with schizophrenia can however not explain why the "voices" drain the attentional and cognitive capacity of the patients, making them unable to direct attention away from the "voices" and to cognitively suppress the experience. We recently reported how AVHs interfere with the perception of speech sounds, using a dichotic listening experimental paradigm. We now extend this finding by reporting on the interference caused by AVHs on attention and cognitive control, using a slight variation of the same dichotic listening paradigm. The patients (N = 148) were instructed to pay attention to and report from either the right or left ear syllable of the dichotic pair. We then correlated their PANSS score for the hallucination item (P3) with the performance score on the dichotic listening task. The results showed that AVHs interfered with the ability to report the right ear syllable when instructed to pay attention to the right side, which is a marker of inability to attend to an external speech stimulus. When instructed to pay attention to the left side, AVHs interfered with the ability to report the left ear syllable, which is a marker of inability to use cognitive control to suppress attending to the "voices". The corresponding correlations for the emotional withdrawal (N2) negative symptom were all non-significant. The correlations were substantiated in an ANOVA with corresponding significant group differences between high versus low symptom score groups. The results thus extend our previous findings of a perceptual origination for AVHs by showing that AVHs interfere with the ability to attend to the outer world around the patient, and the ability to inhibit, or suppress, the "voices" once they occur. Future research should pin down the neuronal basis of both the origination and the attentional and cognitive control aspects of AVHs. (C) 2013 Elsevier B. V. All rights reserved.