Genetic latent structure analysis of dysmorphology in attention deficit disorder.
Genetic latent structure analysis of dysmorphology in attention deficit disorder.
复制标题
注意缺陷障碍畸形的遗传潜在结构分析。
DOI：
10.1097/00004583-199003000-00006
复制
发表时间：
1990
影响因子：
13.3
通讯作者：
Farkas,LG
中科院分区：
文献类型：
--
作者：
Deutsch,CK;Matthysse,S;Swanson,JM;Farkas,LG
在患有注意力缺陷障碍（ADD）的儿童中，以轻微身体异常的形式出现的畸形经常被报道。作者报告了在ADD先证者及其一级亲属中轻微生理异常的过度代表。此外，不畸形的ADD先证有畸形的非ADD亲属；这种家族模式表明，一个单一的潜在因素可能影响这两种性状的遗传。用遗传潜伏结构模型来描述该因子的传播方式。在这个分析中，常染色体显性模型出现了。成功拟合这个模型并不等于测试模型本身的有效性。该模型的有意义的测试将需要比目前可用的更大的样本，并且将受益于ADD和畸形表型的诊断改进。
Dysmorphology—in the form of minor physical anomalies—has been frequently reported in children with attention deficit disorder (ADD). The authors report an overrepresentation of minor physical anomalies in both ADD probands and their first-degree relatives. Further, ADD probands who are not dysmorphic have non-ADD relatives who are dysmorphic; this familial pattern suggests that a single underlying factor may influence transmission of both traits. A genetic latent structure model was fit to these data to describe the factor's mode of transmission. In this analysis, an autosomal dominant model emerged. Successfully fitting this model is not equivalent to testing the validity of the model itself. Meaningful tests of the model will require larger samples than available at present, and would benefit from diagnostic refinement of the ADD and dysmorphic phenotypes.