Protein Termini.
Protein Termini.
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蛋白质末端。
DOI：
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发表时间：
2017
影响因子：
2.8
通讯作者：
Oliviero Carugo
中科院分区：
文献类型：
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作者：
Oliviero Carugo
由于蛋白质的第一个和最后一个残基具有独特的性质，在所有残基中都是独一无二的，因此在过去的几十年中对它们进行了反复分析。在这篇简短的评论中，我试图总结一下，除了生化作用之外，最受关注的五个特征：（i）N端和C端之间的欧几里德距离及其与蛋白质折叠的相关性，（ii）末端暴露于溶剂的原因，（iii）末端的骨架构象，（iv）末端的氨基酸组成，以及（v）末端在蛋白质结晶中的作用。由于存在大量数据，这五个问题中的每一个都值得关注，并附有我个人对该领域研究的看法。
Since the first and the last residues of a protein have peculiar properties, unique amongst all residues, they have been analyzed repeatedly during the last decades. In this brief review, I try to summarize, besides the biochemical roles, the five features that have attracted most attention: (i) the Euclidean distance between the N- and C-termini and its relevance to protein folding, (ii) the reason why the termini are solvent exposed, (iii) the backbone conformation of the termini, (iv) the amino acid composition of the termini, and (v) the role of the termini in protein crystallization. Each of these five issues, which deserve attention nowadays thanks to the availability of massive amounts of data, is accompanied by my personal outlook of the research in the field.