New Alkylitaconic Acid Derivatives from Nodulisporium sp. A21 and Their Auxin Herbicidal Activities on Weed Seeds
New Alkylitaconic Acid Derivatives from Nodulisporium sp. A21 and Their Auxin Herbicidal Activities on Weed Seeds
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来自球孢属的新烷基康酸衍生物。
DOI：
10.1021/acs.jafc.8b04996
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发表时间：
2019
影响因子：
6.1
通讯作者：
Ye Yonghao
中科院分区：
文献类型：
--
作者：
Cao Lingling;Yan Wei;Gu Chenguang;Wang Zhiyang;Zhao Shuangshuang;Kang Shuang;Khan Babar;Zhu Hailiang;Li Jun;Ye Yonghao
从内生真菌Nodulisporiumsp.的发酵培养物中分离得到5个烷基亚硝酸（AA）衍生物，其中包括2个新化合物- A21。在实验室条件下研究了化合物1 - 4对杂草种子的生长素除草活性。一般而言，测试化合物在低剂量下显示胚根生长促进活性，在较高剂量下显示抑制活性。化合物1和2在50 ~ 200 μg mL-1浓度范围内对双子叶杂草平卧草和波斯婆婆纳的胚根生长有显著的抑制作用，而化合物3在相同浓度范围内对胚根生长有显著的促进作用。这些结果表明，这些AA衍生物有可能被用作新的生长素除草剂开发的主导支架。此外，根据13 C标记实验推测了1 - 4的生物合成途径。
Five alkylitaconic acid (AA) derivatives, including two novel compounds, epideoxysporothric acid (2) and sporochartine F (5), and three known compounds, deoxysporothric acid (1), deoxyisosporothric acid (3), and 1-undecen-2,3-dicarboxylic acid (4), were obtained from the fermentation culture of the endophytic fungusNodulisporiumsp. A21. The auxin herbicidal activities of compounds1–4against weed seeds were investigated under laboratory conditions. In general, the tested compounds displayed radicle growth promoting activity at low doses and inhibitory activity at higher doses. Compounds1and2could significantly inhibit the radicle growth of dicotyledon weeds,Eclipta prostrataandVeronica persica, at a concentration range from 50 to 200 μg mL–1, while3notably stimulated radicle growth at the same concentration range. The results suggested that these AA derivatives have the potential to be used as the lead scaffold for novel auxin herbicide development. In addition, the biosynthetic pathways of1–4were deduced based on13C labeling experiment.