Chronic graft-versus-host disease in rats after syngeneic bone marrow transplantation.
Chronic graft-versus-host disease in rats after syngeneic bone marrow transplantation.
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同基因骨髓移植后大鼠的慢性移植物抗宿主病。
DOI：
10.1097/00007890-198505000-00009
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发表时间：
1985
期刊：
影响因子：
6.2
通讯作者：
Cramer,DV
中科院分区：
文献类型：
--
作者：
Oaks,MK;Cramer,DV
在大鼠中进行同基因和异基因骨髓移植后，观察到与人骨髓移植后观察到的慢性移植物抗宿主病（cGVHD）相似的疾病。通过使用AUG/AUG.2B和PVG/PVG，在RT 2红细胞抗原位点同基因或基因不同的供体和受体之间交换骨髓移植物。2A同源对供体/受体菌株组合。在最初的健康期（移植后120-180天）后，几个AUC和AUC. 2B同基因或RT 2不匹配的骨髓受体出现了与cGVHD相容的临床体征。该疾病的临床体征包括：红斑、弥漫性脱发、皮肤皱褶增厚和结膜炎。实验室检查结果包括外周血嗜酸性粒细胞增多和混合淋巴细胞反应中对第三方脾细胞的体外增殖反应受损。有限数量的cGVHD大鼠组织的组织学检查显示表皮下单核细胞炎症伴表皮和皮肤附件萎缩，以及淋巴组织的浆细胞增生。没有PVG或PVG。2A例同基因或RT 2不匹配的受者发生cGVHD。
A disease similar to the chronic graft-versus-host disease (cGVHD) seen following transplantation of human bone marrow was observed after syngeneic and allogeneic bone marrow transplantation in rats. Bone marrow grafts were exchanged between donors and recipients that were syngeneic or genetically different for the RT2 erythrocyte antigen locus by the use of AUG/AUG. 2B and PVG/PVG. 2A congenic pair donor/recipient strain combinations. After an initial period of well-being (120–180 days posttransplantation), several AUG and AUG. 2B recipients of syngeneic or RT2-mismatched bone marrow developed clinical signs compatible with cGVHD. The clinical signs of the disease included: erythema, diffuse alopecia, thickened skin folds, and conjunctivitis. Laboratory findings included peripheral blood eosinophilia and impaired in-vitro proliferative responses to third-party spleen cells in the mixed lymphocyte reaction. Histological examination of the tissues of a limited number of rats with cGVHD showed subepidermal mononuclear inflammation with atrophy of the epidermis and adnexa of the skin, as well as plasmacytic hyperplasia of the lymphoid tissues. None of the PVG or PVG. 2A recipients of syngeneic or RT2-mismatched marrow developed cGVHD.