Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species
Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species
复制标题
DOI：
10.1128/aac.02192-15
复制
发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Bonacorsi, Stephane
中科院分区：
文献类型：
--
作者：
Bidet, Philippe;Basmaci, Romain;Bonacorsi, Stephane
我们描述了一株产青霉素酶的Kingella kingae菌株(KWG1)的基因组，这是在欧洲大陆第一次分离到Kingella kingae菌株，其bla(TEM-1)基因在该物种中首次被发现是染色体插入的。BlA基因位于插入Met-tRNA的整合和结合元件(ICE)中，包含对磺胺类、链霉素和四环素耐药的基因。这种ICE与国王克雷伯氏菌和其他革兰氏阴性细菌的耐药质粒同源。
We describe the genome of a penicillinase-producing Kingella kingae strain (KWG1), the first to be isolated in continental Europe, whose bla(TEM-1) gene was, for the first time in this species, found to be chromosomally inserted. The bla(TEM) gene is located in an integrative and conjugative element ( ICE) inserted in Met-tRNA and comprising genes that encode resistance to sulfonamides, streptomycin, and tetracycline. This ICE is homologous to resistance-conferring plasmids of K. kingae and other Gramnegative bacteria.