Non-hyperammonaemia valproate-induced encephalopathy: A case report
Non-hyperammonaemia valproate-induced encephalopathy: A case report
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非高氨血症丙戊酸诱发的脑病：一例报告
DOI：
10.1111/jcpt.13511
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发表时间：
2021
影响因子：
2
通讯作者：
Huang Hao
中科院分区：
文献类型：
--
作者：
Chen Ling;Xu Zucai;Huang Hao
研究现状与目的：丙戊酸钠是一种有效的抗癫痫药物。丙戊酸钠的严重不良反应不常见。该病例报告说明了存在非高氨血症丙戊酸盐诱导的脑病。案例描述：1例47岁女性癫痫患者，在丙戊酸钠治疗后发生丙戊酸盐诱导的脑病，无高氨血症，停用丙戊酸钠后症状完全消退。什么是新的和结论：早期诊断和确定非高氨血症丙戊酸盐诱导的脑病的机制非常重要。立即停用丙戊酸钠可使这些患者的症状迅速消退。
What is known and objective: Valproate sodium is an effective antiepileptic drug (AED). Serious adverse effects of valproate sodium are uncommon. This case report illustrates the existence of non‐hyperammonaemia valproate‐induced encephalopathy. Case description: A 47‐year‐old woman with epilepsy who developed valproate‐induced encephalopathy without hyperammonaemia after valproate sodium treatment, and the symptoms completely subsided after withdrawal of valproate sodium. What is new and conclusion: Early diagnosis and identification of the mechanisms of non‐hyperammonaemia valproate‐induced encephalopathy are important. Immediate discontinuation of valproate sodium results in rapid resolution of symptoms in these patients.