Molecular mechanisms of bile duct development.
Molecular mechanisms of bile duct development.
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DOI：
10.1016/j.biocel.2010.06.020
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发表时间：
2011-02
影响因子：
4
通讯作者：
Stanger, Ben Z.
中科院分区：
文献类型：
--
作者：
Zong, Yiwei;Stanger, Ben Z.
哺乳动物的胆道系统由肝内和肝外胆管组成，负责将胆汁从肝脏输送到肠道。胆管功能障碍，如在一些先天性胆道疾病如Alagille综合征和胆道闭锁中所见，可导致胆汁在肝脏中积聚，阻止解毒产物的排泄，最终导致肝损伤。胆管形成需要协调的细胞-细胞相互作用，导致细胞分化和形态发生的调节。多种信号分子和转录因子已被确定为胆管发育的重要调控因子。本文综述了该领域的最新进展。从胆管发育的分子机制研究中获得的见解有可能揭示新的分化和形态发生机制以及胆管疾病治疗的潜在靶点。
The mammalian biliary system, consisting of the intrahepatic and extrahepatic bile ducts, is responsible for transporting bile from the liver to the intestine. Bile duct dysfunction, as is seen in some congenital biliary diseases such as Alagille syndrome and biliary atresia, can lead to the accumulation of bile in the liver, preventing the excretion of detoxification products and ultimately leading to liver damage. Bile duct formation requires coordinated cell-cell interactions, resulting in the regulation of cell differentiation and morphogenesis. Multiple signaling molecules and transcription factors have been identified as important regulators of bile duct development. This review summarizes recent progress in the field. Insights gained from studies of the molecular mechanisms of bile duct development have the potential to reveal novel mechanisms of differentiation and morphogenesis in addition to potential targets for therapy of bile duct disorders.
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