BIOLOGICAL EFFECTS OF A PURIFIED LIPOPOLYSACCHARIDE FROM BACTEROIDES GINGIVALIS
BIOLOGICAL EFFECTS OF A PURIFIED LIPOPOLYSACCHARIDE FROM BACTEROIDES GINGIVALIS
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DOI：
10.1111/j.1600-0765.1983.tb00333.x
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发表时间：
1983-01-01
影响因子：
3.5
通讯作者：
HAUSMANN, E
中科院分区：
文献类型：
--
作者：
NAIR, BC;MAYBERRY, WR;HAUSMANN, E
脂多糖 (LPS) 从牙龈芽孢杆菌中纯化。该 LPS 的纯度通过超速离心、免疫电泳和化学分析得到证明。与来自需氧肠道生物的 LPS 相比，当测试兔子的热原性和小鼠脾细胞的有丝分裂活性时，来自牙龈芽孢杆菌的 LPS 表现出最小的效力。从牙龈芽胞杆菌中纯化的 LPS 具有高效能，能够刺激预先标记的胎鼠骨骼释放 45Ca，并抑制 Ca 流入破骨细胞样细胞。
Lipopolysaccharide (LPS) was purified from B. gingivalis. The purity of this LPS is evidenced on ultracentrifugation, immunoelectrophoresis and chemical analyses. On comparison with LPS from aerobic enteric organisms, LPS from B. gingivalis exhibits minimal potency when tested for pyrogenicity in rabbits and mitogenicity in mouse spleen cells. Purified LPS from B. gingivalis exhibits high potency in its ability to stimulate 45Ca release from prelabeled fetal rat bones and to inhibit Ca influx into osteoclast-like cells.