Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging
Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging
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DOI：
10.1148/radiol.2293021299
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发表时间：
2003-12-01
期刊：
影响因子：
19.7
通讯作者：
de Leon, MJ
中科院分区：
文献类型：
--
作者：
Rusinek, H;De Santi, S;de Leon, MJ
目得：为了确定内侧颞叶（MTL）萎缩率是否可以预测未来的记忆力下降，在一项为期6年的三个时间点的纵向研究的初始时间间隔内使用自动程序进行评估。健康老年受试者（年龄，>60岁）进行了一系列全面的神经心理测试，并在基线和两个或两个以上的随访时进行了磁共振（MR）成像。升考试。基线和首次随访检查之间的脑萎缩率通过使用自动化程序进行评估，该程序包括两个图像的空间配准和区域脑边界移位分析。在最后的观察中，45名受试者被分为一组，一组没有表现出认知能力下降的客观证据。一个向前逐步逻辑回归模型被用来确定变量，预测decline.RESULTS：32名受试者保持健康，13人表现出认知能力下降。在表现出认知能力下降的受试者中，有6人在第二次观察后下降。MTL萎缩率，通过其与性别和年龄的交互作用，是下降的最重要的预测因素。预测的总体准确性为89%（40 45例），91%的特异性（29 32例）和85%的敏感性（11 13例）。结论：在健康的老年人中，MTL萎缩率增加似乎是未来记忆力下降的预测。(C)RSNA，2003年。
PURPOSE: To determine if medial temporal lobe (MTL) atrophy rate, assessed by using an automated procedure over the initial time interval of a 6-year, three-time-point longitudinal study, is predictive of future memory decline.MATERIALS AND MET HODS: Healthy elderly subjects (age, >60 years) were administered a comprehensive battery of neuropsychometric tests and underwent magnetic resonance (MR) imaging at baseline and two or more follow-up examinations. The rate of brain atrophy between the baseline and first follow-up examinations was assessed by-using an automated procedure that included spatial coregistration of the two images and regional brain boundary shift analysis. At final observation, the 45 subjects were separated into a group of those who did and a group of those who did not show objective evidence of cognitive decline. A forward stepwise logistic regression model was used to identify variables that predicted decline.RESULTS: Thirty-two subjects remained healthy, and 13 showed cognitive decline. Among subjects who showed cognitive decline, six declined after the second observation. MTL atrophy rate, through its interadions with sex and age, was the most significant predictor of decline. The overall accuracy of prediction was 89% (in, 40 of 45 subjects), with 91% specificity (in, 29, of 32 subjects) and 85% sensitivity (in 11 of 13 subjects).CONCLUSION: Among healthy elderly individuals, increased MTL atrophy rate appears to be predictive of future memory decline. (C) RSNA, 2003.