Bone ingrowth into dynamically loaded porous-coated intramedullary nails.
Bone ingrowth into dynamically loaded porous-coated intramedullary nails.
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骨向动态加载的多孔涂层髓内钉内生长。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
S. Brown
中科院分区：
文献类型：
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作者：
J. P. Collier;G. Colligan;S. Brown
使用兔胫骨作为适合人体骨骼生长的模型进行了研究，以确定多孔涂层维生素髓内棒是否可用于桥接长骨的节段性缺损。通过手术切除成熟兔子胫骨中轴的一厘米部分，并用同等尺寸的硅橡胶管代替，以保持腿的长度。将涂覆的杆插入近端胫骨段、穿过管子并进入远端骨段。 3周后将腿从石膏中取出，并定期进行X光检查直至处死。术后 30 周处死时，在扭转试验机中破坏性地测量了每只兔子双侧胫骨的机械性能。具有节段缺损的胫骨失效时的负载平均为对侧对照胫骨的 90%。杆拔出数据和电子探针 X 射线微分析表明，由于向内生长到多孔涂层中，存在大量的杆-骨内骨结合。扭转数据可能因硅橡胶管上生长的骨愈伤组织的存在而有些模糊，并且在每种情况下都在骨外桥接节段性缺损。
Research to determine whether porous-coated Vitallium intramedullary rods could be used to bridge segmental defects in long bones was performed using rabbit tibias as a suitable model for human bone growth. One-centimeter segments of the midshaft of tibias of mature rabbits were removed surgically and replaced with equal-sized segments of Silastic tubing to maintain leg length. A coated rod was inserted through the proximal tibial segment, through the tubing, and into the distal bone segment. The legs were taken out of plaster at 3 weeks, and x-rays were taken periodically until sacrifice. At sacrifice, 30 weeks postoperatively, the mechanical properties of both tibias from each rabbit were measured destructively in a torsional testing machine. The load at failure of the tibia with the segmental defect averaged 90% of the contralateral control tibia. Rod pullout data and electron-probe x-ray micro-analysis indicated that a substantial rod-endosteal bone bond existed due to ingrowth into the porous coating. The torsional data may have been somewhat obscured by the presence of bony callus which grew over the Silastic tubing and bridged the segmental defect exosteally in every case.