Long-term fatty fish consumption and renal cell carcinoma incidence in women
Long-term fatty fish consumption and renal cell carcinoma incidence in women
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DOI：
10.1001/jama.296.11.1371
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发表时间：
2006-09-20
影响因子：
120.7
通讯作者：
Ekman, Peter
中科院分区：
文献类型：
--
作者：
Wolk, Alicja;Larsson, Susanna C.;Ekman, Peter
背景食用多脂鱼可能与多种癌症的较低风险相关的流行病学证据并不一致，并且没有针对肾细胞癌（RCC）的研究。目的探讨女性食用多脂鱼和瘦肉鱼与RCC风险之间的关系。设计、设置和参与者瑞典乳腺X线摄影队列，一项以人群为基础的前瞻性队列研究，纳入61433名年龄在40 - 76岁之间、基线时无癌症诊断的女性（1987年3月1日至1990年12月14日）。参与者在基线和1997年9月填写了一份食物频率调查问卷。主要结果测量事件肾细胞cancer.Results在平均15.3年（940357人年）的后续1987年至2004年，150例事件肾细胞癌被诊断。调整潜在混杂因素后，发现脂肪鱼消费与RCC风险呈负相关（趋势P = 0.02），但与瘦肉鱼消费无关。与不食用相比，每周食用一次或更多次脂肪鱼的女性的多变量率比（RR）为0.56（95%置信区间[CI]，0.35-0.91）。与一贯报告不吃鱼的女性相比，多变量RR为0.26（95% CI，0.10-0.67）对于那些在基线和1997年报告持续食用脂肪鱼的妇女（基于填写基线和1997年问卷的36664名妇女的子集，在1998-2004年的随访期间，40例RCC病例发生）。结论我们的研究表明，食用脂肪鱼可能会减少女性RCC的发生。
Context The epidemiological evidence that fatty fish consumption may be associated with the lower risk of several cancers is not consistent and no studies of renal cell carcinoma (RCC) exist.Objective To examine the association between fatty and lean fish consumption and risk of RCC in women.Design, Setting, and Participants The Swedish Mammography Cohort, a population-based prospective cohort study of 61 433 women aged 40 to 76 years without previous diagnosis of cancer at baseline ( March 1, 1987-December 14, 1990). Participants filled in a food frequency questionnaire at baseline and in September 1997.Main Outcome Measure Incident renal cell carcinoma.Results During a mean of 15.3 years ( 940 357 person-years) of follow-up between 1987 and 2004, 150 incident RCC cases were diagnosed. After adjustment for potential confounders, an inverse association of fatty fish consumption with the risk of RCC was found ( P for trend=.02), but no association was found with lean fish consumption. Compared with no consumption, the multivariate rate ratio (RR) was 0.56 ( 95% confidence interval [CI], 0.35-0.91) for women eating fatty fish once a week or more. Compared with women consistently reporting no fish consumption, the multivariate RR was 0.26 ( 95% CI, 0.10-0.67) for those women reporting consistent consumption of fatty fish at baseline and 1997 ( based on a subset of 36 664 women who filled in the baseline and 1997 questionnaires, with 40 incident RCC cases during the 1998-2004 follow-up period).Conclusion Our study suggests that consumption of fatty fish may reduce the occurrence of RCC in women.