Prevalence of primary adult lactose malabsorption in three populations of northern China
Prevalence of primary adult lactose malabsorption in three populations of northern China
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DOI：
10.1007/bf00270566
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发表时间：
2004
期刊：
影响因子：
5.3
通讯作者：
Yongfa Wang;Yongshan Yan;Jiujin Xu;D. Ruofu;Sibylle D. Flatz;Wolfgang Kühnau;Gebhard Flatz
中科院分区：
文献类型：
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作者：
Yongfa Wang;Yongshan Yan;Jiujin Xu;D. Ruofu;Sibylle D. Flatz;Wolfgang Kühnau;Gebhard Flatz
对641名明显健康的青少年和成年人（447名男性和194名女性，平均年龄为22.9岁，年龄范围为16-46岁）的乳糖吸收能力进行了现场版的乳糖耐量试验和呼气氢测定。共鉴定出89个乳糖吸收蛋白和552个乳糖吸收不良蛋白。乳糖吸收不良最常见于中国东北汉族亚群（248例受试者中229例，占92.3%）。198名内蒙古蒙古族人中，乳糖吸收不良者174人，占87.9%。乳糖吸收不良发生率最低的是来自新疆西北地区的传统牧民哈萨克族（149 / 195），占76.4%。据报道，乳糖不耐受症状在乳糖吸收不良者中更为常见。北汉的研究结果与南方（主要是海外）中国人乳糖吸收不良的报告频率相似，并且与中国传统饮食中缺乏动物奶相一致。哈萨克族中乳糖吸收不良的患病率相对较低，这表明乳糖持久性可能在西南亚的放牧人群中很常见。
Lactose absorption capacity was examined in 641 apparently healthy adolescents and adults (447 males and 194 females with an average age of 22.9 years and an age range of 16–46 years) using a field version of the lactose tolerance test with breath hydrogen determination. In the total sample, 89 lactose absorbers and 552 lactose malabsorbers were identified. Lactose malabsorption was most frequent in a subgroup of Han (Chinese) from northeastern China (229 of 248 subjects, 92.3%). Among 198 Mongols from Inner Mongolia, there were 174 lactose malabsorbers (87.9%). The frequency of lactose malabsorption was lowest in a group of Kazakhs, traditional herders from the northwestern region of Xinjiang (149 of 195 subjects, 76.4%). Reported symptoms of lactose intolerance were significantly more frequent in lactose malabsorbers. The findings in northern Han are similar to the reported lactose malabsorption frequency in southern (mainly overseas) Chinese, and correspond with the absence of animal milk from traditional Chinese diets. The relatively low prevalence of lactose malabsorption among the Kazakhs suggests that lactose persistence may be frequent in herding pastoralist populations of southwest Asia.