Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis
Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis
复制标题
对精神病超高风险受试者的肠道微生物组和磁共振波谱研究可能支持膜假说。
DOI：
10.1016/j.eurpsy.2018.05.011
复制
发表时间：
2018-09-01
影响因子：
7.8
通讯作者：
Chen, Xiaogang
中科院分区：
文献类型：
--
作者：
He, Ying;Kosciolek, Tomasz;Chen, Xiaogang
背景：脑内微生物区系-肠道-脑轴和膜功能障碍日益引起精神病学研究领域的关注。然而，肠道微生物区系和脑功能在精神分裂症前驱期的可能交互作用尚未被研究。方法：我们采集了81名高危(HR)受试者、19名超高危(UHR)受试者和69名健康对照(HC)的粪便样本并进行了磁共振波谱(MRS)扫描。结果：与其他两组相比，UHR受试者粪便标本中梭状芽胞杆菌、乳杆菌和拟杆菌属的含量均有所增加。肠道微生物区系组成的变化表明，短链脂肪酸(SCFAs)的产生增加，从而激活小胶质细胞，从而扰乱膜代谢。此外，膜功能障碍的脑成像标志物胆碱水平的升高也证实了这一点，与HR组和HC组相比，UHR组的胆碱水平也显著升高。结论：UHR组的肠道微生物组和影像研究均提示脑膜功能障碍，因此可能支持精神分裂症的膜功能障碍假说。(C)2018年爱思唯尔·马森SAS。版权所有。
Background: The microbiota-gut-brain axis and membrane dysfunction in the brain has attracted increasing attention in the field of psychiatric research. However, the possible interactive role of gut microbiota and brain function in the prodromal stage of schizophrenia has not been studied yet.Methods: To explore this, we collected fecal samples and performed Magnetic Resonance Spectroscopy (MRS) scans in 81 high risk (HR) subjects, 19 ultra-high risk (UHR) subjects and 69 health controls (HC). Then we analyzed the differences in gut microbiota and choline concentrations in the anterior cingulate cortex (ACC).Results: Presences of the orders Clostridiales, Lactobacillales and Bacteroidales were observed at increase levels in fecal samples of UHR subjects compared to the other two groups. The composition changes of gut microbiota indicate the i ncreased production of Short Chain Fatty Acids (SCFAs), which could activate microglia and then disrupt membrane metabolism. Furthermore, this was confirmed by an increase of choline levels, a brain imaging marker of membrane dysfunction, which is also significantly elevated in UHR subjects compared to the HR and HC groups.Conclusion: Both gut microbiome and imaging studies of UHR subjects suggest the membrane dysfunction in the brain and hence might support the membrane hypothesis of schizophrenia. (c) 2018 Elsevier Masson SAS. All rights reserved.