Detection of autoimmune regulator gene mutations in children with type 2 autoimmune hepatitis and extrahepatic immune-mediated diseases
Detection of autoimmune regulator gene mutations in children with type 2 autoimmune hepatitis and extrahepatic immune-mediated diseases
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DOI：
10.1016/j.jpeds.2005.01.050
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发表时间：
2005-06-01
影响因子：
5.1
通讯作者：
Jacquemin, E
中科院分区：
文献类型：
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作者：
Lankisch, TO;Strassburg, CP;Jacquemin, E
3例2型抗免疫性肝炎及肝外免疫性疾病患儿中发现自身免疫调节基因突变，其中1例肝移植后免疫性肝炎复发。这些发现表明，自身免疫调节基因变异可能使儿童容易患系统性自身免疫性疾病、免疫疾病复发，或两者兼而有之。
Autoimmune regulator gene mutations were identified in 3 children with type 2 antoimmune hepatitis and extrahepatic immune diseases, including 1 child with immune hepatitis recurrence after liver transplantation. These findings suggest that autoimmune regulator gene variants might predispose children to systemic autoimmune disease, a recurrence of immune disease, or both.