Diffusion MRI for prediction of response of rectal cancer to chemoradiation
Diffusion MRI for prediction of response of rectal cancer to chemoradiation
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DOI：
10.1016/s0140-6736(02)09520-x
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发表时间：
2002-07-27
期刊：
影响因子：
168.9
通讯作者：
Doran, S
中科院分区：
文献类型：
--
作者：
Dzik-Jurasz, A;Domenig, C;Doran, S
在治疗开始前预测肿瘤反应可能会有相当大的临床益处。由于肿瘤水分含量的表观扩散系数(ADC)可以显示肿瘤的坏死程度，我们寻找ADC与治疗反应的可能相关性。我们用定量磁共振扩散成像序列测量了14例局部进展期直肠癌患者化疗和放化疗前后肿瘤水的平均ADC值。治疗前肿瘤平均水分ADC值与化疗后肿瘤大小变化率呈显著负相关(r=-0.67，p=0.001)。化疗后反应者持续低ADC值可能代表接受治疗的肿瘤失去了一部分存活的肿瘤。
Prediction of tumour response before onset of treatment could have considerable clinical benefit. Since the apparent diffusion coefficient (ADC) of a tumour's water content can show the extent of necrosis, we looked for a possible correlation of ADC with response to treatment. We measured mean tumour water ADC before and after chemotherapy and chemoradiation in 14 patients, with locally advanced rectal cancer, with a quantitative magnetic resonance diffusion imaging sequence. We found a strong negative correlation between mean pretreatment tumour water ADC and percentage size change of tumours after chemotherapy (r=-0.67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a nonviable fraction of the treated tumour.