Reduced gamma oscillation during visual processing of the mother's face in children with autism spectrum disorder: A pilot study
Reduced gamma oscillation during visual processing of the mother's face in children with autism spectrum disorder: A pilot study
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自闭症谱系障碍儿童母亲面部视觉处理过程中伽马振荡减少：一项试点研究
DOI：
10.1002/pcn5.68
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Chiaki Hasegawa; Takashi Ikeda; Yuko Yoshimura; Hirokazu Kumazaki; Daisuke N. Saito; Ken Yaoi; Kyung‐Min An; Tetsuya Takahashi; Masayuki Hirata; Minoru Asada; Mitsuru Kikuchi.
中科院分区：
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作者：
荒武由利子;藤井ちひろ;藤田理奈;篠藤裕也;井谷久美;濱谷美緒;峠理絵;近藤誉之;芦田真士 藤井ちひろ 越智博文 濱谷美緒 錦織隆成 高田真基 高橋良輔 水野敏樹 近藤誉之;Chiaki Hasegawa; Takashi Ikeda; Yuko Yoshimura; Hirokazu Kumazaki; Daisuke N. Saito; Ken Yaoi; Kyung‐Min An; Tetsuya Takahashi; Masayuki Hirata; Minoru Asada; Mitsuru Kikuchi.
AimThis study aimed to investigate gamma oscillations related to face processing of children with autism spectrum disorders and typically developed children using magnetoencephalography.MethodsWe developed stimulations that included naturalistic real真实的time eye‐gaze situations between participants and their mothers. 18名患有自闭症谱系障碍的幼儿（62 - 97个月）和24名发育正常的儿童（61 - 79个月）被纳入研究。在双侧颞上沟、梭状回和距突周围皮质的频率范围为30-59和61-90 Hz的脑磁图数据进行了分析。计算伽马振荡归一化值以比较面部状况（儿童凝视母亲的脸）和对照测量（基线）使用以下公式：（面部控制）/结果显示，低γ波段的γ振荡归一化值存在显著差异（30-59 Hz）在右颞上级沟、右侧梭状回和右侧距状突周围皮层的差异。此外，有显着差异，在高伽玛波段（61-90赫兹）的右侧银行的上级颞沟，双侧梭状回，和双边的pericalcarine cortex groups.ConclusionThis报告是第一次脑磁图研究揭示非典型的脸处理自闭症谱系障碍的幼儿使用相关的刺激之间的参与者和他们的母亲。我们的自然主义范式提供了一个有用的评估社会沟通的特点和有价值的洞察自闭症谱系障碍儿童的潜在神经机制。
AimThis study aimed to investigate gamma oscillations related to face processing of children with autism spectrum disorders and typically developed children using magnetoencephalography.MethodsWe developed stimuli that included naturalistic real‐time eye‐gaze situations between participants and their mothers. Eighteen young children with autism spectrum disorders (62−97 months) and 24 typically developed children (61−79 months) were included. The magnetoencephalography data were analyzed in the bilateral banks of the superior temporal sulcus, fusiform gyrus, and pericalcarine cortex for frequency ranges 30–59 and 61–90 Hz. The gamma oscillation normalized values were calculated to compare the face condition (children gazing at mother's face) and control measurements (baseline) using the following formula: (face − control)/(face + control).ResultsThe results revealed significant differences in gamma oscillation normalized values in the low gamma band (30–59 Hz) in the right banks of the superior temporal sulcus, right fusiform gyrus, and right pericalcarine cortex between children with autism spectrum disorders and typically developed children. Furthermore, there were significant differences in gamma oscillation normalized values in the high gamma band (61–90 Hz) in the right banks of the superior temporal sulcus, bilateral fusiform gyrus, and bilateral pericalcarine cortex between the groups.ConclusionThis report is the first magnetoencephalography study revealing atypical face processing in young children with autism spectrum disorders using relevant stimuli between participants and their mothers. Our naturalistic paradigm provides a useful assessment of social communication traits and a valuable insight into the underlying neural mechanisms in children with autism spectrum disorders.