Mannose receptor as a potential biomarker for gastric cancer: a pilot study
Mannose receptor as a potential biomarker for gastric cancer: a pilot study
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DOI：
10.5301/jbm.5000244
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发表时间：
2017-07-01
影响因子：
2
通讯作者：
Kang, Hong-Xia
中科院分区：
文献类型：
--
作者：
Liu, Deng-Rui;Guan, Quan-Lin;Kang, Hong-Xia
背景资料：甘露糖受体是一种免疫粘附分子，主要表达在抗原呈递细胞如未成熟树突状细胞和巨噬细胞的表面上。本研究旨在探讨甘露糖受体在乳头状胃癌患者中的表达及其预测价值。方法：采用免疫组化和实时荧光定量PCR方法检测120例胃癌组织及癌旁组织中甘露糖受体的表达。结果：甘露糖受体在胃癌组织中的表达率为45.8%（54/120），显著高于癌旁组织（20.0%，36/120）（χ 2 = 6.286，p = 0.012）。甘露糖受体的高表达与胃癌的肿瘤大小、T分期、N分期及UICC分期密切相关（p
Background: The mannose receptor is an immune adhesion molecule mainly expressed on the surface of antigen-presenting cells such as nonmature dendritic cells and macrophages. This study aimed to investigate mannose receptor expression and its predictive role in papillary gastric cancer patients.Methods: The expression of the mannose receptor was measured in 120 samples of gastric cancer tissues and corresponding paracarcinoma tissues, by immunohistochemical and quantitative real-time PCR analysis. The relationships between mannose receptor expression and clinicopathological features of gastric cancer patients were analyzed.Results: The expression rate of the mannose receptor in gastric cancer cells was 45.8% (54/120), significantly higher than that in the paracarcinoma tissue (20.0%, 36/120) (chi(2) = 6.286, p = 0.012). High expression of the mannose receptor was closely related to tumor size, T stage, N stage and Union for International Cancer Control (UICC) stage of gastric cancer (p