Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: Technique and sensitivity
Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: Technique and sensitivity
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DOI：
10.1109/tmi.2005.844159
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发表时间：
2005-04-01
影响因子：
10.6
通讯作者：
Frangi, AF
中科院分区：
文献类型：
--
作者：
Cebral, JR;Castro, MA;Frangi, AF
血流动力学因素被认为与颅内动脉瘤的进展和破裂有关。目前的努力旨在研究血流动力学特征的可能关联，如颅内血流模式的复杂性和稳定性，血流冲击区域的大小和位置与颅内破裂的临床病史。然而，没有可靠的方法来测量体内的血流模式。在本文中，描述了一种有效的方法，用于从医学图像中对脑动脉瘤的血流动力学进行患者特定的建模和表征。在预期的生理范围内的条件下的几个变量的变化的血流动力学特性的灵敏度分析也提出。这种敏感性分析表明，虽然可以观察到速度场的变化，但当平均输入流量、流量划分、粘度模型或网格分辨率发生变化时，内循环流型的特征不会改变。还发现，对计算的流场具有较大影响的变量是血管结构的几何形状。我们的结论是，与建议的建模管道临床研究涉及大量脑动脉瘤是可行的。
Hemodynamic factors are thought to be implicated in the progression and rupture of intracranial aneurysms. Current efforts aim to study the possible associations of hemodynamic characteristics such as complexity and stability of intra-aneurysmal flow patterns, size and location of the region of flow impingement with the clinical history of aneurysmal rupture. However, there are no reliable methods for measuring blood flow patterns in vivo. In this paper, an efficient methodology for patient-specific modeling and characterization of the hemodynamics in cerebral aneurysms from medical images is described. A sensitivity analysis of the hemodynamic characteristics with respect to variations of several variables over the expected physiologic range of conditions is also presented. This sensitivity analysis shows that although changes in the velocity fields can be observed, the characterization of the intra-aneurysmal flow patterns is not altered when the mean input flow, the flow division, the viscosity model, or mesh resolution are changed. It was also found that the variable that has the greater impact on the computed flow fields is the geometry of the vascular structures. We conclude that with the proposed modeling pipeline clinical studies involving large numbers cerebral aneurysms are feasible.