Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer.
Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer.
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DOI：
10.1038/sj.bjc.6602536
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发表时间：
2005-05-09
影响因子：
8.8
通讯作者：
Nakano, H
中科院分区：
文献类型：
--
作者：
Yagi, H;Miyamoto, S;Tanaka, Y;Sonoda, K;Kobayashi, H;Kishikawa, T;Iwamoto, R;Mekada, E;Nakano, H
表皮生长因子受体（EGFR）与卵巢癌的肿瘤生长和扩展有关。卵巢癌患者的腹腔液中含有多种生长因子，可以促进肿瘤的生长和扩展。为了研究EGFR配体作为卵巢癌激活因子的临床意义，我们检测了99例患者腹腔液中的细胞增殖促进活性和EGFR配体水平。 63 名卵巢癌患者 (OVCA) 的腹腔液中的增殖促进活性远高于 18 名卵巢囊肿患者 (OVC) 和 18 名正常卵巢患者 (NO) 的腹腔液，并且该活性仅被抗 EGFR 或肝素结合表皮生长因子 (HB-EGF) 的抗体抑制。 HB-EGF 和 TGF-α 或双调蛋白之间的 EGFR 配体水平存在很大差异。 OVCA中HB-EGF浓度较OVC或NO显着升高(P<0.01)。 OVCA 组与 NO 或 OVC 组之间 TGF-α 和双调蛋白浓度没有显着差异。在腹膜液中，即使在 OVCA 的早期阶段，HB-EGF 也足以激活癌细胞。这些结果表明腹腔液中的 HB-EGF 可能在细胞存活和 OVCA 增殖中发挥关键作用。
Epidermal growth factor receptor (EGFR) has been implicated in tumour growth and extension of ovarian cancer. Peritoneal fluid in ovarian cancer patients contains various growth factors that can promote tumour growth and extension. In order to investigate the clinical significance of EGFR ligands as activating factors of ovarian cancer, we examined the cell proliferation-promoting activity and the level of EGFR ligands in peritoneal fluid obtained from 99 patients. Proliferation-promoting activity in peritoneal fluid from 63 ovarian cancer patients (OVCA) was much higher than peritoneal fluid from 18 ovarian cyst patients (OVC) and 18 normal ovary patients (NO), and the activity was suppressed only by antibodies against EGFR or heparin-binding epidermal growth factor (HB-EGF). A large difference was observed in the level of EGFR ligands between HB-EGF and TGF-α or amphiregulin. The concentration of HB-EGF in OVCA significantly increased compared to that in OVC or NO (P<0.01). No significant difference in the concentration of TGF-α and amphiregulin was found between the OVCA and NO or OVC groups. In peritoneal fluid, HB-EGF is sufficiently elevated to activate cancer cells even at an early stage of OVCA. These results suggested that HB-EGF in peritoneal fluid might play a key role in cell survival and in the proliferation of OVCA.
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影响因子：
45.3
作者：
Baselga, J;Rischin, D;Albanell, J
通讯作者：
Albanell, J
影响因子：
11.4
作者：
Gschwind, A;Hart, S;Ullrich, A
通讯作者：
Ullrich, A
影响因子：
11.2
作者：
Miyamoto, S;Hirata, M;Mekada, E
通讯作者：
Mekada, E
影响因子：
19.6
作者：
TAN, MS;TSAI, JC;TSAI, JH
通讯作者：
TSAI, JH
影响因子：
2.9
作者：
Xiao, YJ;Schwartz, B;Xu, Y
通讯作者：
Xu, Y