HIP/PAP, a member of the reg family, is expressed in glucagon-producing enteropancreatic endocrine cells and tumors
HIP/PAP, a member of the reg family, is expressed in glucagon-producing enteropancreatic endocrine cells and tumors
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DOI：
10.1016/j.humpath.2006.03.005
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发表时间：
2006-08-01
期刊：
影响因子：
3.3
通讯作者：
Scoazec, Jean-Yves
中科院分区：
文献类型：
--
作者：
Hervieu, Valerie;Christa, Laurence;Scoazec, Jean-Yves
肝癌-肠-胰腺/胰腺炎相关蛋白（HIP/PAP）是reg家族的一员，在消化道和胰腺中由一些特化的上皮细胞亚群组成性表达。我们进行了详细的分析，HIP/PAP蛋白的表达在正常的消化内分泌细胞根据其定位，谱系和分化阶段，并在消化内分泌肿瘤根据其原产地和激素配置文件的网站。在成人和胎儿正常组织中，HIP/PAP表达仅在小肠、升结肠和胰腺的内分泌细胞中检测到。鉴定了两种不同的表达模式：（a）在消化粘膜的内分泌细胞和专门合成胰高血糖素和胰高血糖素样肽的朗格汉斯岛外缘中观察到强细胞质标记;（B）在其他胰腺内分泌细胞群中观察到弱细胞质免疫反应性。在184例接受检查的消化内分泌肿瘤中，36例检测到HIP/PAP表达;其中32例（89%）为胰腺肿瘤。保留了在正常状态下观察到的2种模式：（a）在26个肿瘤中5%至100%的肿瘤细胞中观察到强标记，所有肿瘤均表达胰高血糖素或胰高血糖素样肽;（B）在10个肿瘤中存在弱标记，呈现各种激素特征。总之，HIP/PAP的强表达是产生胰高血糖素的正常和肿瘤性肠胰腺内分泌细胞的特征。我们的研究结果提供了进一步的支持的概念，reg家族的成员在各种内分泌细胞群中发挥调节作用，它们在内分泌细胞中的表达是谱系特异性的。(c)2006年由Elsevier Inc.出版
Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive endocrine cells according to their localization, lineage, and differentiation stage, and in digestive endocrine tumors according to their site of origin and hormonal profile. In both adult and fetal normal tissues, HIP/PAP expression was detected only in endocrine cells of the small intestine, ascending colon, and pancreas. Two different expression patterns were identified: (a) a strong cytoplasmic labeling observed in the endocrine cells of the digestive mucosa and the outer rim of Langerhans islets specialized in the synthesis of glucagon and glucagon-like peptides; (b) a weak cytoplasmic immumoreactivity observed in the other pancreatic endocrine cell populations. HIP/PAP expression was detected in 36 of the 184 cases of digestive endocrine tumors examined; 32 of these cases (89%) were pancreatic. The 2 patterns observed in the normal state were retained: (a) a strong labeling was observed in 5% to 100% of tumor cells in 26 tumors, all expressing glucagon or glucagon-like peptides; (b) a weak labeling was present in 10 tumors, presenting various hormonal profiles. In conclusion, a strong expression of HIP/PAP is characteristic of glucagon-producing normal and neoplastic enteropancreatic endocrine cells. Our results lend further support to the concept that members of the reg family play regulatory roles in various endocrine cell populations and that their expression in endocrine cells is lineage-specific. (c) 2006 Published by Elsevier Inc.