Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea
Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea
复制标题
南海柳珊瑚 Dichotella gemmacea 的防污荠菜烷型二萜类化合物
DOI：
10.1016/j.tet.2012.10.102
复制
发表时间：
2013-01-14
期刊：
影响因子：
2.1
通讯作者：
Liu, Yonghong
中科院分区：
文献类型：
--
作者：
Sun, Jian-Fan;Han, Zhuang;Liu, Yonghong
通过对南海柳珊瑚Dichotella gemmacea的进一步研究，共分离到16个新的briarane型二萜化合物dichotellides F-U（1-16），沿着18个已知的类似物（17-34）。通过MS、1D和2D NMR谱分析及与文献报道的化合物的结构比较，确定了它们的结构。单晶X射线衍射数据证实了15的绝对构型。抗肿瘤试验表明，化合物3、4、6-11、16和23在无毒浓度下具有有效的抗肿瘤活性，其EC 50值分别为4.1、1.82、6.3、7.6、4.6、1.2、5.6、0.79、2.0和0.2 μ g/mL。(c)2012爱思唯尔有限公司保留所有权利。
Our continued investigation on the South China Sea gorgonian Dichotella gemmacea led to the isolation of 16 new briarane-type diterpenoids, dichotellides F-U (1-16), along with 18 known analogues (17-34). Their structures were determined by MS, 1D and 2D NMR spectra analyses and by comparison with those reported in literature. The absolute configuration of 15 was confirmed by single-crystal X-ray diffraction data. The antifouling test showed that compounds 3, 4, 6-11, 16, and 23 had potent antifouling activities at nontoxic concentrations with EC50 values of 4.1, 1.82, 6.3, 7.6, 4.6, 1.2, 5.6, 0.79, 2.0, and 0.2 mu g/mL, respectively. (c) 2012 Elsevier Ltd. All rights reserved.