Prevalence and influence of hypouricemia on cardiovascular diseases in patients with rheumatoid arthritis.
Prevalence and influence of hypouricemia on cardiovascular diseases in patients with rheumatoid arthritis.
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DOI：
10.1186/s40001-022-00888-5
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发表时间：
2022-11-21
影响因子：
4.2
通讯作者：
Dai, Lie
中科院分区：
文献类型：
--
作者：
Zou, Yao-Wei;Li, Qian-Hua;Zhu, Ying-Ying;Pan, Jie;Gao, Jing-Wei;Lin, Jian-Zi;Wu, Tao;Zhang, Qian;Zheng, Hu-Wei;Mo, Ying-Qian;Ma, Jian-Da;Dai, Lie
Serum uric acid (SUA) acts as an antioxidant and abnormally low SUA may raise the risk of developing atherosclerotic disorders. There is a U-shaped association between SUA with cardiovascular diseases (CVDs) in general population. However, the prevalence of hypouricemia and its influence on CVDs in rheumatoid arthritis (RA) remains unclear. This cross-sectional study collected clinical data from a Chinese RA cohort. Hypouricemia was defined as SUA ≤ 3.0 mg/dL, and hyperuricemia was defined as SUA ≥ 7.0 mg/dL. CVDs were defined as a history of angina pectoris, myocardial infarction, heart failure, stroke and peripheral arterial disease. Restricted cubic spline regression and logistic regression analysis were conducted to evaluate the associations between SUA levels and CVDs. Among 1130 RA patients recruited, the mean age was 53.2 years and 79.0% were female. The prevalence of hypouricemia and hyperuricemia were 10.6% and 12.0%, respectively. RA patients with hyperuricemia had a higher rate of CVDs than normouricemic patients (27.9% vs. 7.1%, P < 0.05). Surprisingly, RA patients with hypouricemia also had a higher rate of CVDs (20.7% vs. 7.1%, P < 0.05) even without higher traditional cardiovascular risk factors. A U-shaped association between SUA levels and total CVDs was found (Pnon-linear < 0.001). Multivariate logistic regression analysis revealed that compared with normouricemia, both hypouricemia [adjusted OR (AOR) = 4.707, 95% CI 2.570–8.620] and hyperuricemia (AOR = 3.707, 95% CI 2.174–6.321) were associated with higher risk of CVDs. Hypouricemia may be a potential risk factor of CVDs in RA patients The online version contains supplementary material available at 10.1186/s40001-022-00888-5.
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影响因子：
4.7
作者：
Chiou, Andrew;England, Bryant R.;Mikuls, Ted R.
通讯作者：
Mikuls, Ted R.
糖甜饮料的消耗与早期发病的中国男性痛风患者的肥胖和更高的血清尿酸有关。
影响因子：
5
作者：
Li, Qian-Hua;Zou, Yao-Wei;Lian, Shu-Yan;Liang, Jin-Jian;Bi, Yu-Fei;Deng, Chao;Mo, Ying-Qian;Yang, Kui-Min;Dai, Lie
通讯作者：
Dai, Lie
影响因子：
4.4
作者：
Beberashvili, Ilia;Sinuani, Inna;Averbukh, Zhan
通讯作者：
Averbukh, Zhan
影响因子：
2.1
作者：
Ma, J-D;Chen, C-T;Dai, L.
通讯作者：
Dai, L.
DOI：
10.15420/ecr.2020.44
发表时间：
2021-03
期刊：
European cardiology
影响因子：
--
作者：
Kerola AM;Rollefstad S;Semb AG
通讯作者：
Semb AG