(99m)Tc-3P-RGD2 molecular imaging targeting integrin α(v)β(3) in head and neck squamous cancer xenograft.
(99m)Tc-3P-RGD2 molecular imaging targeting integrin α(v)β(3) in head and neck squamous cancer xenograft.
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DOI：
10.1007/s10967-015-3928-5
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发表时间：
2015
影响因子：
1.6
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
Yan B;Qiu F;Ren L;Dai H;Fang W;Zhu H;Wang F
99mTc-3P-RGD2 and SPECT/CT were valuable tools for selecting patient likely benefit from integrin α v β 3 blocking therapy. To evaluate the feasibility of 99mTc-3P-RGD2 imaging to detect head and neck squamous cell carcinoma, 99mTc-3P-RGD2 was prepared and the relationship between its accumulation and integrin α v β 3 expression in nude mice bearing HEP-2 or CNE-1 carcinoma xenograft were analyzed. This study demonstrated that 99mTc-3P-RGD2, with high affinity to integrin α v β 3, will provide basis for α v β 3 involved individual therapy.
