cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway.
cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway.
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DOI：
10.1016/j.bbamem.2006.06.001
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发表时间：
2006-08
期刊：
影响因子：
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通讯作者：
F. Umenishi;T. Narikiyo;A. Vandewalle;R. Schrier
中科院分区：
文献类型：
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作者：
F. Umenishi;T. Narikiyo;A. Vandewalle;R. Schrier
本研究调查了 AVP 诱导的 AQP2 表达的调节。 AVP 给药以剂量依赖性方式诱导 AQP2 表达，并与细胞内 cAMP 浓度增加相关。 AVP 刺激 PKA 活性，但 PKA 抑制剂不能阻断 AQP2 表达的上调。然而，AVP 还激活 ERK 和 CREB 通路，并且 ERK 抑制剂减弱 AQP2 表达的上调。因此，这些结果表明 AVP 刺激上调 AQP2 表达的作用涉及 PKA 独立途径。
The regulation of AVP-induced AQP2 expression was investigated in the present study. AVP administration induced AQP2 expression in a dose-dependent manner in association with an increase in intracellular cAMP concentration. PKA activity was stimulated by AVP but PKA inhibitors did not block the upregulation of AQP2 expression. However, AVP also activated both ERK and CREB pathways, and ERK inhibitor attenuated the upregulation of AQP2 expression. These results therefore indicate that the effect of AVP stimulation to upregulate AQP2 expression involves a PKA-independent pathway.