Melanoma risk in association with serum leptin levels and lifestyle parameters: a case-control study
Melanoma risk in association with serum leptin levels and lifestyle parameters: a case-control study
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DOI：
10.1093/annonc/mdm464
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发表时间：
2008-02-01
影响因子：
50.5
通讯作者：
Petridou, E. T.
中科院分区：
文献类型：
--
作者：
Gogas, H.;Trakatelli, M.;Petridou, E. T.
背景资料：太阳辐射已被确定为导致黑色素瘤的主要因素，而与肥胖和糖尿病相关的生活方式的改变也可能导致恶性肿瘤发病率的增加。没有研究调查瘦素的作用，一种激素，其水平增加肥胖，这也与cancer.Patients和方法：55例黑色素瘤患者和165年龄和性别匹配的健康对照组进行了采访的基础上的问卷调查，包括表型特征，社会人口和病史变量，生活习惯和频率的消费的主要食物组。同时记录人体测量数据，并采集血样测定血清瘦素水平。结果：在控制了肥胖指数、糖尿病和受教育程度等因素后，对阳光敏感者和瘦素循环水平高者患黑色素瘤的风险增加（OR：1.56，95%可信区间1.07-2.28，P = 0.02）。增加体育锻炼，降低酒精消费和植物性食物的消费似乎发挥了保护作用，对黑色素瘤development.Conclusions：黑色素瘤的风险被认为是正相关的血清瘦素水平和健康的生活方式因素呈负相关。这些发现需要在前瞻性研究中得到证实。
Background: Solar radiation has been identified as a principal factor for the causation of melanoma, whereas changing lifestyle patterns associated with obesity and diabetes might also contribute to the increasing incidence of the malignancy. No study has investigated the role of leptin, a hormone whose levels increase in obesity and which has also been related to cancer.Patients and methods: Fifty-five patients with incident melanomas and 165 age- and gender-matched healthy controls were interviewed on the basis of a questionnaire that covers phenotypic features, sociodemographic and medical history variables, lifestyle habits and frequency of consumption of major food groups. Anthropometrical measures were also recorded and blood samples were obtained for determination of serum leptin levels. Adjusted odds ratios (ORs) for melanoma risk were derived through multiple logistic regression analyses.Results: An excess melanoma risk was observed for sun sensitive individuals and those with high circulating levels of leptin (OR: 1.56, 95% confidence interval 1.07-2.28, P = 0.02), after controlling for obesity indices, diabetes mellitus and education. Increased physical exercise, lower alcohol consumption and plant food consumption seem to play a protective role against melanoma development.Conclusions: Melanoma risk was found to be positively associated with serum leptin levels and inversely with healthy lifestyle factors. The findings need to be confirmed in prospective studies.