Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships
Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships
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DOI：
10.1111/obr.13128
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发表时间：
2020-08-26
期刊：
影响因子：
8.9
通讯作者：
Shekar, Meera
中科院分区：
文献类型：
--
作者：
Popkin, Barry M.;Du, Shufa;Shekar, Meera
个人肥胖与新冠肺炎之间的联系存在争议，缺乏系统的研究。在对新冠肺炎上的中英文文献进行系统搜索后，共使用了75项研究，对肥胖与新冠肺炎之间的关系进行了一系列荟萃分析，涵盖了从风险到死亡率的全过程。对新冠肺炎和肥胖个体的发病机制进行了系统的综述。合并分析显示，肥胖患者患新冠肺炎阳性的风险增加46.0%(OR=1.46；95%CI，1.3-1.65；P<；0.0001)；住院风险增加113%(OR=2.13；95%CI，1.74-2.60；P<；0.0001)；住ICU，高74%(OR=1.74；95%CI，1.46-2.08)；死亡率，死亡增加48%(OR=1.48；95%的可信区间为1.22-1.8；P<；0.001)。对于与新冠肺炎风险、严重性及其在这些个体中减少治疗和预防治疗的潜力相关的因素，深入介绍了肥胖个体的机制路径。肥胖个体与新冠肺炎的发病率和死亡率的大幅增加有关。有许多机制共同解释了这种影响。一个主要的担忧是，疫苗对肥胖者的效果将会降低。
The linkage of individuals with obesity and COVID-19 is controversial and lacks systematic reviews. After a systematic search of the Chinese and English language literature on COVID-19, 75 studies were used to conduct a series of meta-analyses on the relationship of individuals with obesity-COVID-19 over the full spectrum from risk to mortality. A systematic review of the mechanistic pathways for COVID-19 and individuals with obesity is presented. Pooled analysis show individuals with obesity were more at risk for COVID-19 positive, >46.0% higher (OR = 1.46; 95% CI, 1.30-1.65;p< 0.0001); for hospitalization, 113% higher (OR = 2.13; 95% CI, 1.74-2.60;p< 0.0001); for ICU admission, 74% higher (OR = 1.74; 95% CI, 1.46-2.08); and for mortality, 48% increase in deaths (OR = 1.48; 95% CI, 1.22-1.80;p< 0.001). Mechanistic pathways for individuals with obesity are presented in depth for factors linked with COVID-19 risk, severity and their potential for diminished therapeutic and prophylactic treatments among these individuals. Individuals with obesity are linked with large significant increases in morbidity and mortality from COVID-19. There are many mechanisms that jointly explain this impact. A major concern is that vaccines will be less effective for the individuals with obesity.