Ethanol Susceptibility of SARS-CoV-2 and Other Enveloped Viruses
Ethanol Susceptibility of SARS-CoV-2 and Other Enveloped Viruses
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DOI：
10.4265/bio.26.177
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发表时间：
2021-01-01
影响因子：
1.2
通讯作者：
Sakaguchi, Takemasa
中科院分区：
文献类型：
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作者：
Nomura, Toshihito;Nazmul, Tanuza;Sakaguchi, Takemasa
乙醇是对抗新型冠状病毒SARS-CoV-2的有效消毒剂。然而，其有效浓度尚未显示，因此我们分析了不同浓度的乙醇对SARS-CoV-2的影响。当用不同浓度的乙醇处理SARS-CoV-2并检查感染性的变化时，99%的感染滴度降低的乙醇浓度为24.1%（w/w）[29.3%（v/v）]。作为参考，还用其他包膜病毒检查了乙醇敏感性，包括流感病毒、弹状病毒科的水泡性口炎病毒和副粘病毒科的纽卡斯尔病病毒，发现99%抑制浓度为28.8%（w/w）[34.8%（v/v）]、24.0%（w/w）[29.2%（v/v）]、和13.3%（w/w）[16.4%（v/v）]。与SARS-CoV-2相比，有一定差异，但差异不显著。得出的结论是，浓度为30%（w/w）[36.2%（v/v）]的乙醇几乎完全灭活SARS-CoV-2。
Ethanol is an effective disinfectant against the novel coronavirus SARS-CoV-2. However, its effective concentration has not been shown, and we therefore analyzed the effects of different concentrations of ethanol on SARS-CoV-2. When SARS-CoV-2 was treated with varying ethanol concentrations and examined for changes in infectivity, the ethanol concentration at which 99% of the infectious titers were reduced was 24.1% (w/w) [29.3% (v/v)]. For reference, ethanol susceptibility was also examined with other envelope viruses, including influenza virus, vesicular stomatitis virus in the family Rhabdoviridae, and Newcastle disease virus in the family Paramyxoviridae, and the 99% inhibitory concentrations were found to be 28.8% (w/w) [34.8% (v/v)], 24.0% (w/w) [29.2% (v/v)], and 13.3%(w/w) [16.4% (v/v) , respectively. Some differences from SARS-CoV-2 were observed, but the differences were not significant. It was concluded that ethanol at a concentration of 30% (w/w) [36.2%(v/v)] almost completely inactivates SARS-CoV-2.