Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the basolateral amygdala: Heterosynaptic induction mechanisms of late-LTP
Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the basolateral amygdala: Heterosynaptic induction mechanisms of late-LTP
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DOI：
10.1523/jneurosci.21-10-03697.2001
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发表时间：
2001-05-15
影响因子：
5.3
通讯作者：
Frey, JU
中科院分区：
文献类型：
--
作者：
Frey, S;Bergado-Rosado, J;Frey, JU
基底外侧杏仁核（BLA）可以影响不同的学习和记忆形成。海马长时程增强 (LTP) 是记忆形成的最重要的细胞模型，可以通过在其诱导和早期维持过程中刺激 BLA 来调节。然而，尚不清楚 LTP 初始阶段之后的后期维护可能会受到怎样的影响。行为刺激已被证明可以将短暂的早期 LTP 增强为持久的增强。在这里，我们表明，当 BLA 在穿通路径强直之前或之后 30 分钟的时间窗口内被激活时，BLA 刺激模拟了自由活动大鼠对早期 LTP 的行为影响。 LTP 的增强被毒蕈碱能和β-肾上腺素能受体的抑制剂阻断，但多巴胺能受体的抑制剂则不然，并且依赖于翻译。通过这些异质突触关联相互作用，海马感觉信息可以通过杏仁核的影响来稳定。
The basolateral amygdala (BLA) can influence distinct learning and memory formation. Hippocampal long- term potentiation (LTP), the most prominent cellular model of memory formation, can be modulated by stimulation of the BLA in its induction and early maintenance. However, it is not known how the late maintenance of LTP beyond its initial phases might be affected. Behavioral stimuli have been shown to result in a reinforcement of a transient early- LTP into a lasting potentiation. Here we show that BLA stimulation mimics the behavioral effects on early- LTP in freely moving rats when the BLA is activated within a time window of 30 min before or after tetanization of the perforant path. The reinforcement of LTP was blocked by inhibitors of muscarinergic and beta- adrenergic but not dopaminergic receptors and was dependent on translation. Through these heterosynaptic associative interactions, hippocampal sensory information can be stabilized by amygdaloidal influences.