Diffusion MRI of complex neural architecture
Diffusion MRI of complex neural architecture
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DOI：
10.1016/s0896-6273(03)00758-x
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发表时间：
2003-12-04
期刊：
影响因子：
16.2
通讯作者：
Wedeen, VJ
中科院分区：
文献类型：
--
作者：
Tuch, DS;Reese, TG;Wedeen, VJ
虽然功能性脑成像方法可以定位特定认知功能的皮层区域，但人类大脑功能区域之间的连接仍然知之甚少。最近，研究人员提出了一种方法，图像神经连接非侵入性使用磁共振成像方法称为扩散张量成像（DTI）。DTI测量水分子沿沿着神经通路的扩散。然而，由于DTI无法在每个成像体素内分辨出多于一个轴突方向，因此从DTI准确重建神经连接模式受到阻碍。在这里，我们提出了一种新的磁共振成像技术，可以解决多个轴突方向在一个单一的体素。这项技术，称为q球成像，可以解决体素内白色物质纤维交叉以及白色物质插入皮质。q-ball成像解决复杂的体素内纤维结构的能力消除了非侵入性映射人脑神经连接的关键障碍。
While functional brain imaging methods can locate the cortical regions subserving particular cognitive functions, the connectivity between the functional areas of the human brain remains poorly understood. Recently, investigators have proposed a method to image neural connectivity noninvasively using a magnetic resonance imaging method called diffusion tensor imaging (DTI). DTI measures the molecular diffusion of water along neural pathways. Accurate reconstruction of neural connectivity patterns from DTI has been hindered, however, by the inability of DTI to resolve more than a single axon direction within each imaging voxel. Here, we present a novel magnetic resonance imaging technique that can resolve multiple axon directions within a single voxel. The technique, called q-ball imaging, can resolve intravoxel white matter fiber crossing as well as white matter insertions into cortex. The ability of q-ball imaging to resolve complex intravoxel fiber architecture eliminates a key obstacle to mapping neural connectivity in the human brain noninvasively.