The lipid droplet-a well-connected organelle.
The lipid droplet-a well-connected organelle.
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DOI：
10.3389/fcell.2015.00049
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发表时间：
2015
影响因子：
5.5
通讯作者：
Goodman JM
中科院分区：
文献类型：
--
作者：
Gao Q;Goodman JM
近年来，我们对细胞间通讯的了解呈指数级增长。本文综述了细胞质脂滴与其他细胞器的相互作用。25年前，液滴仅仅被认为是脂肪凝聚的微粒。十年前，蛋白质组学研究提示液滴可能与其他结构相互作用以共享脂质和蛋白质。现在很清楚，液滴与许多（如果不是大多数的话）细胞结构相互作用，以维持细胞内稳态，并缓冲诸如饥饿等损害。提出了这一说法的证据，以及了解液滴相互作用的性质和结果的探针。
Our knowledge of inter-organellar communication has grown exponentially in recent years. This review focuses on the interactions that cytoplasmic lipid droplets have with other organelles. Twenty-five years ago droplets were considered simply particles of coalesced fat. Ten years ago there were hints from proteomics studies that droplets might interact with other structures to share lipids and proteins. Now it is clear that the droplets interact with many if not most cellular structures to maintain cellular homeostasis and to buffer against insults such as starvation. The evidence for this statement, as well as probes to understand the nature and results of droplet interactions, are presented.