Spontaneous stereotypy in an animal model of Down syndrome: Ts65Dn mice.
Spontaneous stereotypy in an animal model of Down syndrome: Ts65Dn mice.
复制标题
唐氏综合症动物模型中的自发刻板：Ts65Dn 小鼠。
DOI：
10.1023/a:1012226603255
复制
发表时间：
2001
影响因子：
2.6
通讯作者：
Lewis,MH
中科院分区：
文献类型：
--
作者：
Turner,CA;Presti,MF;Newman,HA;Bugenhagen,P;Crnic,L;Lewis,MH
Stereotyped behaviors (e.g., body rocking) occur at high rates in individuals with mental retardation (e.g., Down syndrome). To determine if spontaneous stereotypy occurs in a murine model of Down syndrome, the home cage behavior of Ts65Dn and control mice was monitored during the dark cycle. Motor activity was further assessed in novel automated test chambers, with acoustic startle and rotor rod paradigms providing additional environmental challenges. Spontaneous stereotypy (repetitive jumping and cage top twirling) was observed in the home cage in approximately half of the Ts65Dn mice, compared with approximately 10% of diploid controls. Repetitive jumping was observed exclusively in the Ts65Dn mice. In the open field, although no differences were found between Ts65Dn and control mice, stereotypic Ts65Dn mice exhibited significantly less locomotor activity and rearing relative to control and nonstereotypic Ts65Dn mice. Ts65Dn mice attained significantly lower rotor rod speeds but did not differ from controls in the amplitude of the acoustic startle response. These environmental challenges did not increase stereotypy over home cage rates but induced stereotypy in two additional animals. The Ts65Dn model may aid in identifying genes associated with the development and expression of stereotypy.
