Immunosuppression by anti-CD4 treatment in vivo. Cellular and humoral responses to alloantigens.
Immunosuppression by anti-CD4 treatment in vivo. Cellular and humoral responses to alloantigens.
复制标题
体内抗CD4治疗的免疫抑制。
DOI：
10.1097/00007890-198906000-00024
复制
发表时间：
1989
期刊：
影响因子：
6.2
通讯作者：
Fathman,CG
中科院分区：
文献类型：
--
作者：
Weyand,CM;Goronzy,J;Swarztrauber,K;Fathman,CG
通过体内单克隆抗体（McAb）治疗消除CD4+辅助性T细胞已被用作器官移植和自身免疫性疾病中的免疫抑制的新模式。为了探索这种治疗方法的潜在风险，我们研究了CD4+ T细胞耗竭小鼠的抗病毒反应。
Elimination of CD4+ helper T cells by treatment with monoclonal antibodies (mcAb) in vivo has been used as a new mode of immunosuppression in organ transplantation and autoimmune diseases. To explore the potential risks of this therapeutic approach we have studied antiviral responses in mice depleted of CD4+ T cells.