Toll-like receptors in the uterus, cervix, and placenta: is pregnancy an immunosuppressed state?
Toll-like receptors in the uterus, cervix, and placenta: is pregnancy an immunosuppressed state?
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DOI：
10.1016/j.ajog.2007.06.021
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发表时间：
2007-09-01
影响因子：
9.8
通讯作者：
Elovitz, Michal A.
中科院分区：
文献类型：
--
作者：
Gonzalez, Juan M.;Xu, Hua;Elovitz, Michal A.
目的：这些研究是为了阐明Toll样受体（TLR）在子宫，子宫颈，胎盘在妊娠和跨gestation.Study设计：TLR-2，-3，-4和-9的信息表达进行了研究，在非妊娠小鼠和跨妊娠的CD-1小鼠。收获子宫、宫颈和胎盘组织，并提取RNA。结果：TLRs的mRNA表达在妊娠子宫和宫颈组织中显著上调。TLR信使RNA在子宫、子宫颈和胎盘中的表达存在差异。结论：妊娠期天然免疫系统是一个动态的系统。妊娠期间免疫抑制的概念似乎仅在胎盘TLR表达方面有效。有必要进行研究以确定妊娠期间子宫和宫颈的上调是否与对病原体反应的可能性增加有关，或作为保护机制或两者兼而有之。
OBJECTIVE: These studies were performed to elucidate the expression of Toll-like receptors (TLRs) in the uterus, cervix, and placenta in pregnancy and across gestation.STUDY DESIGN: Message expressions of TLR-2, -3, -4, and -9 were investigated in nonpregnant mice and across gestation in CD-1 mice. Uterine, cervical, and placental tissues were harvested, and RNA was extracted. Quantitative polymerase chain reaction was performed.RESULTS: Messenger RNA expression of TLRs is significantly upregulated in pregnant uterine and cervical tissues. There is differential TLR messenger RNA expression between the uterus, cervix, and placenta. In the placenta, TLR 4 is significantly downregulated.CONCLUSION: These findings suggest that the innate immune system is a dynamic system during gestation. The concept of immunosuppression during pregnancy appears to be valid in the placenta only in regard to TLR expression. Research is warranted to determine whether the upregulation in the uterus and cervix during pregnancy is associated with an increased likelihood of responding to a pathogen or serve as a protective mechanism or both.