Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
复制标题
DOI：
10.1053/jhep.2003.50449
复制
发表时间：
2003-11-01
期刊：
影响因子：
13.5
通讯作者：
Shimotohno, K
中科院分区：
文献类型：
--
作者：
Watashi, K;Hijikata, M;Shimotohno, K
Persistent infection of hepatitis C virus (HCV) is a major cause of liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Searching for a substance with anti-HCV potential, we examined the effects of a variety of compounds on HCV replication using a HCV subgenomic replicon cell culture system. Consequently, the immunosuppressant cyclosporin A (CsA) was found to have a suppressive effect on the HCV replicon RNA level and HCV protein expression in these cells. CsA also inhibited multiplication of the HCV genome in a cultured human hepatocyte cell line infected with HCV using HCV-positive plasma. This anti-HCV activity of CsA appeared to be independent of its immunosuppressive function. In conclusion, our results suggest that CsA may represent a new approach for the development of anti-HCV therapy.
