Histologic types of epithelial ovarian cancer: have they different risk factors?
Histologic types of epithelial ovarian cancer: have they different risk factors?
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DOI：
10.1016/j.ygyno.2004.10.037
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发表时间：
2005-02-01
影响因子：
4.7
通讯作者：
Whittemore, AS
中科院分区：
文献类型：
--
作者：
Kurian, AW;Balise, RR;Whittemore, AS
目标。上皮性卵巢癌的组织学类型在临床行为、描述性流行病学和遗传起源方面有所不同。本研究的目标是进一步明确组织学特异性卵巢癌风险与生殖和生活方式属性的关系。作者对美国白人女性卵巢癌的10个病例对照研究进行了汇总分析，共涉及1834例浸润性上皮性卵巢癌患者(浆液性1067例，粘液性254例，子宫内膜样癌373例，透明细胞140例)和7484例对照妇女。所有四种组织学类型的风险都与产次和口服避孕药的使用呈负相关，但组织学类型与非生殖因素显示出不同的关联。独特的关联包括浆液性癌风险与体重指数呈负相关，粘液性癌风险与吸烟呈正相关，子宫内膜样癌风险与体重指数呈弱正相关。所有组织学类型的风险，与月经初潮年龄、绝经年龄、不孕症病史、非避孕雌激素使用和饮酒无关。卵巢癌风险的最重要的影响因素(产次和口服避孕药的使用)在组织学上显示出相似的相关性。然而，其他修饰物的独特相关性支持这样的猜想，即上皮性卵巢癌的组织类型有不同的病因，这一点应该在未来卵巢癌的分子基础及其治疗反应的研究中得到解决。(C)2004 Elsevier Inc.保留所有权利。
Objectives. The histologic types of epithelial ovarian cancer differ in clinical behavior, descriptive epidemiology, and genetic origins. The goals of the current study were to characterize further the relation of histologic-specific ovarian cancer risks to reproductive and lifestyle attributes.Methods. The authors conducted a pooled analysis of 10 case-control Studies of ovarian cancer in US White women, involving 1834 patients with invasive epithelial ovarian cancer (1067 serous, 254 mucinous, 373 endometrioid, and 140 clear cell) and 7484 control women.Results. Risks of all four histological types were inversely associated with parity and oral contraceptive use, but the histologic types showed different associations with nonreproductive factors. Unique associations include an inverse relation of serous cancer risk to body mass index, a positive relation of mucinous cancer risk to cigarette smoking, and a weakly positive relation of endometrioid cancer risk to body mass index. Risk of all histologic types,vas unassociated with age at menarche, age at menopause, a history of infertility, noncontraceptive estrogen use, and alcohol consumption.Conclusions. The most important modifiers of ovarian cancer risk (parity and oral contraceptive use) showed similar associations across the histologies. Nevertheless, the unique associations seen for other modifiers Support the conjecture that the histologic types of epithelial ovarian cancer have different etiologies, which Should be addressed in future investigations of the molecular basis of ovarian cancers and their responses to therapies. (C) 2004 Elsevier Inc. All rights reserved.