Striatal dopaminergic stimulation produces c-Fos expression in the PPT and an increase in wakefulness
Striatal dopaminergic stimulation produces c-Fos expression in the PPT and an increase in wakefulness
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DOI：
10.1016/s0006-8993(03)03167-6
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发表时间：
2003-10-03
期刊：
影响因子：
2.9
通讯作者：
Giordano, M
中科院分区：
文献类型：
--
作者：
Mena-Segovia, J;Giordano, M
纹状体激活可以改变与特定纹状体功能相关的皮质区域的活动，可能是通过在基底节内解除抑制的过程。解剖学研究表明，从这些核团到桥脑脚被盖核(PPT)有大量GABA能神经支配。因此，刺激纹状体的多巴胺能产生PPT去抑制，并导致非特异性皮质激活。为了验证这一假设，将d-苯丙胺注入自由活动大鼠的纹状体内以记录运动和皮质电记录，并在深度麻醉下向动物纹状体内注入c-fos免疫组织化学。结果表明，纹状体内注射苯丙胺可增加觉醒，而不依赖于运动活动，并增加PPT及邻近区域c-Fos的表达。他们还提示，纹状体参与了非特异性皮质激活，可能是由于它与PPT的关系。(C)2003爱思唯尔B.V.保留所有权利。
Striatal activation can modify activity in cortical areas related to specific striatal functions possibly through a process of disinhibition within the basal ganglia. Anatomical studies have shown substantial GABAergic innervation from these nuclei to the pedunculopontine tegmental nucleus (PPT). Thus, dopaminergic stimulation of the striatum could produce PPT disinhibition and result in non-specific cortical activation. To test this hypothesis, d-amphetamine was infused both into the striatum of freely moving rats for motor and electrocorticographic recordings, and into the striatum of animals under deep anesthesia for c-Fos immunohistochemistry. The results show that intrastriatal amphetamine increases wakefulness independent of motor activity, and it increases c-Fos expression in the PPT and adjacent areas. They also suggest that the striatum participates in non-specific cortical activation probably as a result of its relationship with the PPT. (C) 2003 Elsevier B.V. All rights reserved.