The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold.
The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold.
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DOI：
10.1093/nar/gkw271
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发表时间：
2016-05-19
影响因子：
14.9
通讯作者：
Fox AH
中科院分区：
文献类型：
--
作者：
Knott GJ;Bond CS;Fox AH
核蛋白通常会被赋予一个能反映其功能的简明名称，比如“转录因子”、“聚合酶”或“核受体”。然而，对于果蝇行为/人类剪接(DBHS)蛋白家族的成员来说，没有这样明确的标题。DBHS蛋白经常被发现参与基因调控的几乎每一步，包括但不限于转录调控、RNA加工和运输以及DNA修复。在这里，我们提供了一幅DBHS蛋白的连贯图景，将最近对二聚化、核酸结合方式和寡聚化倾向的结构见解与生物功能结合在一起。这个新出现的范例描述了一个动态蛋白质家族，它调节了广泛的蛋白质-蛋白质和蛋白质-核酸相互作用，总体上起到了多用途分子支架的作用。总体而言，在认识DBHS蛋白的作用方面已经迈出了重要的一步，但我们才刚刚开始了解这个家族在细胞生物学中的复杂性和更广泛的重要性。
Nuclear proteins are often given a concise title that captures their function, such as ‘transcription factor,’ ‘polymerase’ or ‘nuclear-receptor.’ However, for members of the Drosophila behavior/human splicing (DBHS) protein family, no such clean-cut title exists. DBHS proteins are frequently identified engaging in almost every step of gene regulation, including but not limited to, transcriptional regulation, RNA processing and transport, and DNA repair. Herein, we present a coherent picture of DBHS proteins, integrating recent structural insights on dimerization, nucleic acid binding modalities and oligomerization propensity with biological function. The emerging paradigm describes a family of dynamic proteins mediating a wide range of protein–protein and protein–nucleic acid interactions, on the whole acting as a multipurpose molecular scaffold. Overall, significant steps toward appreciating the role of DBHS proteins have been made, but we are only beginning to understand the complexity and broader importance of this family in cellular biology.