Pd-catalyzed asymmetric allylic amination using easily accessible metallocenyl P,N-ligands.
Pd-catalyzed asymmetric allylic amination using easily accessible metallocenyl P,N-ligands.
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DOI：
10.1039/c5ob00032g
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发表时间：
2015-03
影响因子：
3.2
通讯作者：
Hongwei Wu;F. Xie;Yanlan Wang;Xiaohu Zhao;Delong Liu;Wanbin Zhang
中科院分区：
文献类型：
--
作者：
Hongwei Wu;F. Xie;Yanlan Wang;Xiaohu Zhao;Delong Liu;Wanbin Zhang
与C1-对称配体相比，平面手性C2-对称C3-烯基P，N-配体是钯催化的不对称烯丙基胺化反应的有效手性配体，可提供许多具有高对映选择性的胺化产物。一个非C2-对称的二茂铁基P，N-配体（在上述C2-对称物种的合成过程中得到的副产物）也被发现是一个有效的配体不对称烯丙基胺化。考察了由C2-和非C2-对称的二茂铁配合物组成的混合配体体系，该体系表现出很高的催化活性，得到的胺化产物具有优异的对映选择性。
Compared to their C1-symmetric counterparts, planar chiral C2-symmetric metallocenyl P,N-ligands are efficient chiral ligands for Pd-catalyzed asymmetric allylic aminations, providing a number of amination products with high enantioselectivities. A non-C2-symmetric ferrocenyl P,N-ligand (a by-product obtained during the synthesis of the above C2-symmetric species) was also found to be an efficient ligand for asymmetric allylic aminations. A mixed ligand system consisting of both C2- and non-C2-symmetric ferrocene complexes was examined and showed high catalytic activity with the amination products being obtained with excellent enantioselectivities.