Scrub typhus: pathophysiology, clinical manifestations and prognosis
Scrub typhus: pathophysiology, clinical manifestations and prognosis
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DOI：
10.1016/s1995-7645(12)60036-4
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发表时间：
2012-04-01
影响因子：
3.1
通讯作者：
Fernando, Deepika
中科院分区：
文献类型：
--
作者：
Rajapakse, Senaka;Rodrigo, Chaturaka;Fernando, Deepika
恙虫病是由病原体恙虫病东方体 (O. tsutsugamushi) 引起的人畜共患病。该病在东亚和东南亚地区十分流行。通常表现为急性发热性疾病，由于与其他热带发热感染相似，因此经常被漏诊。存在许多不寻常的表现，本综述对这些表现进行了描述，并概述了当前的病理生理学知识。了解这些不寻常的临床表现将有助于临床医生做出早期诊断，从而及早给予适当的抗生素。严重疾病的预后指标尚未明确确定。
Scrub typhus is a zoonosis caused by the pathogen Orientia tsutsugamushi (O. tsutsugamushi). The disease has significant prevalence in eastern and Southeast Asia. Usually presenting as an acute febrile illness, the diagnosis is often missed because of similarities with other tropical febrile infections. Many unusual manifestations are present, and these are described in this review, together with an outline of current knowledge of pathophysiology. Awareness of these unusual clinical manifestations will help the clinician to arrive at an early diagnosis, resulting in early administration of appropriate antibiotics. Prognostic indicators for severe disease have not yet been clearly established.